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myfinalway木虫 (正式写手)
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[交流]
求翻译一段
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One limitation in the use of regular vaccines against AIV or NDV is that vaccinated poultry frequently cannot be differentiated from naturally infected birds, making serological surveillance dif- ficult to perform. However, vaccination of birds with a bivalent vaccine like rNDV_F3aa-chimericH7, which induces an immune response against H7 HA and NDV in chickens, makes serological surveillance against avian influenza possible because vaccinated animals lack immune responses against antigens present in whole influenza. Therefore, our bivalent vaccine would be suitable for use as a ‘‘differentiating infected from vaccinated animals’’ (DIVA) vaccine. NDV vaccines based on lentogenic strains of NDV are widely used in poultry. A chimeric NDV_AIV bivalent vaccine would be administered in the same way as the conventional NDV vaccines, but would confer protection against both NDV and AIV. |
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