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zhangguangrong(½ð±Ò+25,VIP+0): 12-31 22:21
zhangguangrong(½ð±Ò+25,VIP+0): 12-31 22:21
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½üÄêÀ´£¬Ëæ×Å·Ö×Óϸ°û²¡ÀíѧºÍÒÅ´«Ñ§µÄ·¢Õ¹£¬Ñо¿Õß·¢ÏÖȾɫÌåÊýÄ¿ºÍ½á¹¹µÄ»û±äÔÚ°òë×UCÖÐÊ®·Ö³£¼û£¬ Recently, with the development of molecular pathocytology and genetics, researchers find out that the aberration of chromosome number and the distortion of structure are commonly observed in the bladder UC. ¶øFISH×÷Ϊ¼ì²âDNA ÐòÁм°Æä±ä»¯µÄ¼¼Êõ£¬Í¨¹ý¶Ô°òë×UC»¼ÕßÄòÒºÖÐÍÑÂäϸ°û½øÐÐȾɫÌåÒÅ´«Ñ§¸Ä±äµÄ¼ì²â£¬·¢ÏÖÆäÃô¸Ð¶È¸ßÓÚϸ°ûÐÎ̬ѧ·ÖÎö£¬ÌØÒì¶ÈÔòÓëϸ°ûÐÎ̬ѧÏ൱¡£ By examining genetic variation of the chromosome in the exfoliated cells obtained from the bladder UC sufferers¡¯s urine, FISH, a technique employed to detect the NDA sequence and its variation, was shown higher sensitivity than the cell morphology analyses and a comparable specificity to that drawn by cell morphology. ÒòΪUUTճĤÓë°òë×ճĤ¾ßÓÐͬԴÐÔ£¬±íÏÖÔÚUCÉϵÄÒÅ´«Ñ§¸Ä±äÒ²Ïàͬ¡£ The genetic variation of the UUT mucous membrane shown in UC is the same to that of bladder mucous membrane due to their homology. UUT-UC»¼ÕßÁÙ´²ÉÏ´æÔÚÈ¡»î¼ìÏà¶Ô½ÏÄÑÎÊÌ⣬FISHÔò×÷ΪһÖÖ¸ßÃô¸Ð¶ÈÓëÌØÒì¶ÈÇÒÎÞ´´·½·¨ÔòÓÐמߴóµÄÓÅÊÆ As the relatively difficult clinical biopsy of UTT-UC patients, FISH instead has the great advantage owing to its high sensitivity and specificity. |
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