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guoningli金虫 (小有名气)
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| 学科交叉优势互补：本课题为药理学和药物化学交叉研究课题，其中的化合物设计工作是在对金属蛋白酶结构及其周围环境进行充分研究基础上，发挥生物信息学和生物计算技术优势，通过计算机分子动力学模拟、虚拟筛选、定向合成、体内外活性筛选和定量构效关系等环节优化筛选合成的。这是一类全新结构和作用机制的化合物，如果开发成功，不仅将成为第一个具有自主知识产权的新结构慢性肝病防治药物，对于未来研究开发同类型的新药提供生物信息资源。 |
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guoningli(金币+6,VIP+0): 12-25 19:32
zap65535(金币+4,VIP+0):补发 12-28 10:52
guoningli(金币+6,VIP+0): 12-25 19:32
zap65535(金币+4,VIP+0):补发 12-28 10:52
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Interdisciplinary Subjects and Complemented Strengths: This research is a interdisciplinary subject studying on pharmacology and pharmaceutical chemistry, where based on the sufficient studies on the structure of the metal protease and its surrounding environment, research of new compounds designing is been done by taking the advantage of of bio-informatics and bio-computing technologies through the optimized and selective synthesis including the molecular dynamics simulation with computer, virtual selection, directed synthesis, selecting by in-vivo or in-vitro activities and quantitative structure-activity relationship respectively. This is completely a new kind of compound with novel structure and mechanism. If successfully developed, it will become not only the first new entity drug for treatment and prevention of chronic liver disease with independent intellectual property rights, but also a good example for the following new brother drugs coming out from the development in the future by providing the biological information resources. |
2楼2009-12-23 16:43:34
guoningli
金虫 (小有名气)
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- 注册: 2009-04-12
- 专业: 合成药物化学
3楼2009-12-25 19:31:50