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[×ÊÔ´] ¡¾·ÖÏí¡¿ÏÂÔØ£º±í¹Û»ùÒò×éѧ Epigenomics

±í¹Û»ùÒò×éѧ Epigenomics
By Anne Ferguson-Smith, John M. Greally, Robert A. Martienssen

Publisher: Springer
Number Of Pages: 436
Publication Date: 2009-01-01
ISBN-10 / ASIN: 1402091869
ISBN-13 / EAN: 9781402091865
Binding: Hardcover
Product Description:
Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture, integrity and packaging of the chromosome, the accessibility of DNA to regulatory components and the ability of chromatin to interact with functional nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in healthy and in compromised situations. The relationships between the underlying DNA sequence, the dynamic changes in epigenetic states and the consequences of this for the cell or organism, are beginning to emerge as the functions of epigenetic modifications in particular model systems and model organisms are studied. These integrated approaches go hand-in-hand with genome-wide studies describing the location of epigenetic modifications in different cell types at different times that allow functional correlations to be made.

The excitement and curiosity surrounding epigenomics has resulted in a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. This has resulted in a recognition that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.

The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context and to communicate some of the wonders of epigenomics illustrated through examples across the biological spectrum.

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