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ll_l

新虫 (小有名气)

应助: 0 (幼儿园)
金币: 872.2
帖子: 170
在线: 10.3小时
虫号: 24285650

[交流] K-CSC-生命科学博士招生

2026年伦敦国王学院csc项目招生啦！如果你对心脏疾病的诊断和治疗感兴趣，并且想研发或者拓展医学影像mri在疾病诊治中的应用，欢迎联系。更多详细信息请见项目简介：
if you are passionate in a phd project to diagnose and treat heart disease using powerful mri and pet imaging and novel cell-based therapies come and work with us at king’s college london.
https://kcl-mrcdtp.com/project/m ... ponse-to-treatment/
https://www.kcl.ac.uk/study-lega ... hip-programme-k-csc
https://www.kcl.ac.uk/study/post ... uirements#section-3

project title: molecular imaging signatures of fibrosis to detect heart failure and response to treatment

scientific basis: heart failure (hf) affects ~1 million people in the uk (64 million in the world) and is a major driver of morbidity, mortality and nhs costs. cardiac fibrosis (cf), characterised by the excessive accumulation of collagen types 1 and 3 in the myocardium, drives hf. however, current imaging technologies do not directly measure cf, and no specific antifibrotic drugs are available. thus, developing non-invasive imaging technologies and testing the efficacy of new treatments to diagnose and treat cardiac fibrosis selectively is a largely unmet clinical need.

overarching aims: this project will use cutting-edge cardiac mri and newly developed imaging probes to non-invasively detect cardiac fibrosis and provide in vivo biomarkers to diagnose heart failure. the developed biomarkers will then be used to measure the therapeutic efficacy of clinically used and novel anti-fibrotic factors, and the effects of biological sex on therapeutic response. the project will answer the clinically important question whether molecular imaging of collagens can provide readouts for precision imaging of cardiac fibrosis to detect hearts at risk of failing, monitor and guide the development of effective therapeutics to prevent heart failure.

objectives:
1. profile the expression of collagen types 1 and 3 in cardiac fibrosis and determine whether molecular mri of these collagens quantifies cardiac fibrosis and relates to the development of hf in rodents (year 0-1).
2. utilise the developed imaging methodology to assess the therapeutic efficacy of clinically used and novel antifibrotic factors (e.g., chrdl1 and fam3c) delivered via adeno-associated vectors (year 1-2.5).
3. test whether cardiac fibrosis and the efficacy of two novel anti-fibrotic factors depend on biological sex (year 2.5-4.0).
imaging data will be complemented by tissue analysis, including histology, immunohistochemistry, gene expression, and protein immunoblotting.
techniques: animal research training; in vivo cardiac molecular mri (and pet if needed), histology and fluorescence microscopy; cell culture; pcr; western blotting; image analysis, statistics.
(e) the rotation will teach:
1) histology & microscopy. heart sections from mice with myocardial infarction will be stained with masson’s trichrome and picrosirius red (for infarct size and total collagen) and immunostained with antibodies for col1, col3, and fibroblast activation protein (fap) to detect activated fibroblasts.
2) in vivo cardiac molecular mri. the student will shadow cardiac mri scans in mice to learn how to acquire and analyse images to measure cardiac function (e.g. end-diastolic & systolic volumes, ejection fraction) and molecular imaging (area of enhancement after administration of an mri probe).

to apply you will also need a english language exam. both supervisors have excellent track record in the field and supervising students and are excited to work with enthusiastic and committed students on projects that would lead to new discoveries. if you are interested for further details please contact dr alkystis phinikaridou alkystis.1.phinikaridou@kcl.ac.uk

此项目适合有医学或生物学背景的同学，期待具有动物实验和基础医学实验技能和经验的同学。有意向者欢迎发送邮件至导师邮箱： alkystis.1.phinikaridou@kcl.ac.uk 。如果有其他的问题，也欢迎留言，会不定期的查看回复，如果可以的话也麻烦大家分享给适合的同学，祝大家都能找到心仪的岗位和机会。

For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply.

[ Last edited by ll_l on 2025-10-17 at 20:47 ]

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ll_l

新虫 (小有名气)

应助: 0 (幼儿园)
金币: 872.2
帖子: 170
在线: 10.3小时
虫号: 24285650

For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply.