| 查看: 987 | 回复: 11 | |||
[交流]
K-CSC-生命科学博士招生
|
|||
|
2026年伦敦国王学院csc项目招生啦！如果你对心脏疾病的诊断和治疗感兴趣，并且想研发或者拓展医学影像mri在疾病诊治中的应用，欢迎联系。更多详细信息请见项目简介： if you are passionate in a phd project to diagnose and treat heart disease using powerful mri and pet imaging and novel cell-based therapies come and work with us at king’s college london. https://kcl-mrcdtp.com/project/m ... ponse-to-treatment/ https://www.kcl.ac.uk/study-lega ... hip-programme-k-csc https://www.kcl.ac.uk/study/post ... uirements#section-3 project title: molecular imaging signatures of fibrosis to detect heart failure and response to treatment scientific basis: heart failure (hf) affects ~1 million people in the uk (64 million in the world) and is a major driver of morbidity, mortality and nhs costs. cardiac fibrosis (cf), characterised by the excessive accumulation of collagen types 1 and 3 in the myocardium, drives hf. however, current imaging technologies do not directly measure cf, and no specific antifibrotic drugs are available. thus, developing non-invasive imaging technologies and testing the efficacy of new treatments to diagnose and treat cardiac fibrosis selectively is a largely unmet clinical need. overarching aims: this project will use cutting-edge cardiac mri and newly developed imaging probes to non-invasively detect cardiac fibrosis and provide in vivo biomarkers to diagnose heart failure. the developed biomarkers will then be used to measure the therapeutic efficacy of clinically used and novel anti-fibrotic factors, and the effects of biological sex on therapeutic response. the project will answer the clinically important question whether molecular imaging of collagens can provide readouts for precision imaging of cardiac fibrosis to detect hearts at risk of failing, monitor and guide the development of effective therapeutics to prevent heart failure. objectives: 1. profile the expression of collagen types 1 and 3 in cardiac fibrosis and determine whether molecular mri of these collagens quantifies cardiac fibrosis and relates to the development of hf in rodents (year 0-1). 2. utilise the developed imaging methodology to assess the therapeutic efficacy of clinically used and novel antifibrotic factors (e.g., chrdl1 and fam3c) delivered via adeno-associated vectors (year 1-2.5). 3. test whether cardiac fibrosis and the efficacy of two novel anti-fibrotic factors depend on biological sex (year 2.5-4.0). imaging data will be complemented by tissue analysis, including histology, immunohistochemistry, gene expression, and protein immunoblotting. techniques: animal research training; in vivo cardiac molecular mri (and pet if needed), histology and fluorescence microscopy; cell culture; pcr; western blotting; image analysis, statistics. (e) the rotation will teach: 1) histology & microscopy. heart sections from mice with myocardial infarction will be stained with masson’s trichrome and picrosirius red (for infarct size and total collagen) and immunostained with antibodies for col1, col3, and fibroblast activation protein (fap) to detect activated fibroblasts. 2) in vivo cardiac molecular mri. the student will shadow cardiac mri scans in mice to learn how to acquire and analyse images to measure cardiac function (e.g. end-diastolic & systolic volumes, ejection fraction) and molecular imaging (area of enhancement after administration of an mri probe). to apply you will also need a english language exam. both supervisors have excellent track record in the field and supervising students and are excited to work with enthusiastic and committed students on projects that would lead to new discoveries. if you are interested for further details please contact dr alkystis phinikaridou alkystis.1.phinikaridou@kcl.ac.uk 此项目适合有医学或生物学背景的同学，期待具有动物实验和基础医学实验技能和经验的同学。有意向者欢迎发送邮件至导师邮箱： alkystis.1.phinikaridou@kcl.ac.uk 。如果有其他的问题，也欢迎留言，会不定期的查看回复，如果可以的话也麻烦大家分享给适合的同学， 祝大家都能找到心仪的岗位和机会。 For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply. [ Last edited by ll_l on 2025-10-17 at 20:47 ] |
回复此楼» 猜你喜欢
估计是周四
已经有3人回复
-
基金啊基金
已经有3人回复
-
科研孤儿太难了
已经有15人回复
-
让我中一个面上吧！
已经有10人回复
-
言之凿凿，明天官网会通知放榜？
已经有17人回复
-
时间戳又变了
已经有17人回复
-
今天系统多次维护，明天很可能放榜！
已经有11人回复
-
时间戳变了，能看出什么问题？
已经有23人回复
-
只有每年这种时候来逛逛小木虫
已经有22人回复
-
放榜前的不淡定
已经有12人回复
» 抢金币啦！回帖就可以得到:
-
告别流水线爽文！108万字完结仙侠《女娲石之灵石奇缘（仙界篇）》值得细品
+1/4049
-
散金祈福
+3/864
-
每年这时候我都再仔细读一遍《范进中举》
+1/484
-
散金求好运
+1/200
-
山东征女友，坐标济南
+1/91
-
哈尔滨工业大学（校本部）电子与信息工程学院2027级博士招生
+1/68
-
上海交通大学张航课题组招聘博士后（电化学能量存储与转换）
+1/46
-
上海交通大学化学化工学院倪伟焱课题组招收2027年申请考核制博士生（电催化+高分子）
+1/26
-
pcold 原核表达载体
+1/11
-
2027环境工程博士申请
+1/9
-
找女友
+1/6
-
博士答辩现场，博导手机弹出第9条催收短信
+1/5
-
中国科学院生态环境研究中心环境工程相关方向招收保送硕士和联合培养博士和硕士研究生
+1/4
-
北京理工大学-集成电路与电子学院杰青团队-招博士后
+1/3
-
清华大学环境课题组招聘环境工作专业客座生研究生2-3名（应用导向）
+1/2
-
出全新蔡司 Plan?APOCHROMAT 20×/0.8 平场复消色差物镜
+1/2
-
河海大学海洋环境污染与生态毒理学研究组招收2027级硕士生 及博士研究生
+1/2
-
新审查指南施行半年，AI方向的专利申请是不是更看"技术味"了？
+1/2
-
北理工集成电路杰青团队 | 诚招科助理
+1/2
-
清华大学环境课题组招聘环境工作专业客座生研究生2-3名（应用导向）
+1/1
| For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply. |
12楼2025-10-17 20:46:50
简单回复
tfang2楼
2025-10-06 15:51
回复
tzynew3楼
2025-10-06 15:54
回复
ll_l(金币+1): 谢谢参与
k 发自小木虫手机客户端
2025-10-06 16:27
回复
ll_l(金币+1): 谢谢参与
2025-10-06 16:34
回复
ll_l(金币+1): 谢谢参与
2025-10-06 16:39
回复
ll_l(金币+1): 谢谢参与
XG-WUST7楼
2025-10-06 17:29
回复
ll_l(金币+1): 谢谢参与
up 发自小木虫IOS客户端
nono20098楼
2025-10-06 19:27
回复
ll_l(金币+1): 谢谢参与
·
kingluck9楼
2025-10-06 20:20
回复
ll_l(金币+1): 谢谢参与
s9659z10楼
2025-10-06 22:21
回复
ll_l(金币+1): 谢谢参与
lymjjh11楼
2025-10-06 22:41
回复
ll_l(金币+1): 谢谢参与
