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中国海洋大学王杨教授课题组招收“申请-考核”制博士研究生
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一、导师介绍 王杨，教授，博士生导师。2008年本科毕业于中国农业大学，同年保送至北京大学化学与分子工程学院，2013年在北京大学获得有机化学博士学位（导师：席振峰院士，张文雄教授）。之后获得欧盟“玛丽居里”学者计划，在瑞士洛桑联邦理工学院（EPFL）从事博士后研究（导师：Jieping Zhu教授）。2017年至2019年在加拿大西蒙弗雷泽大学（SFU）从事博士后研究（导师：Robert Britton教授）。2019年加入中国海洋大学医药学院独立开展研究工作。2020年入选山东省泰山学者青年专家。在有机化学、药物化学领域具有丰富的经验。在国际期刊上发表具有重要影响力的学术论文20余篇。获得授权专利3项。担任Org. Lett., Chem. Commun., J. Org. Chem., Chin. Chem. Lett.等国际期刊审稿人。 研究方向：有机合成合成方法学、药物合成 已发表论文： 1. Yongxing Zhang, Xiaochen Tian, and Yang Wang.* Asymmetric Catalytic [3+3] Annulations of Unmodified Morita-Baylis-Hillman Alcohols to Construct Diverse Heterobicyclic [4.3.0] Skeletons. JACS Au, 2025, Accepted. 2. Tingting Zhang, Xiaochen Tian, Xin Shua, Honghan Lia, Yihan Lua, Yang Wang.* Indolylmethanols as C4 synthons for the asymmetric synthesis of indole-fused spiro compounds. Chin. J. Chem. 2025, DOI: 10.1002/CJOC.202500911.R1 3. Tengfei Xuan, Xia Wang, Yang Wang.* Asymmetric [3+2] cycloannulation of benzoxazinones for the synthesis of imidazo[5,1‑c]oxazinones. Org. Lett. 2025, 27, 3134. 4. Xin Shu, Tingting Zhang, Yongxing Zhang, Kexin Tong, Shumin Wang, Yang Wang.* Asymmetric construction of enantioenriched spiro gem-diamines via [3+3] annulation of α,β-unsaturated N-sulfonyl ketimines and 3-aminobenzofurans. Org. Chem. Front. 2025, 12, 3643. 5. Tengfei Xuan, Yuan Pan, Zhenyu Shi, Yang Wang.* Organocatalytic asymmetric synthesis of oxazolines from N-acylimines. Chin. Chem. Lett. 2025, 36, 110352. 6. Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang, Yang Wang.* Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids. Nat. Commun. 2024, 15, 6429. 7. Lesong Li, Tao Liu, Weiwu Ren, Yang Wang.* Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines. Green Synth. Catal. 2024, 5, 57. 8. Shuting Zhang, Xinyu Zhang, Lesong Li, Zhenyu Shi, Yang Wang.* Synthesis of pyridazino[4,5-b]indoles by [3+3] annulation of 2-alkenylindoles and hydrazonyl chlorides. Chem. Eur. J. 2024, 30, e202400278. 9. Lesong Li, Congyang Li, Shuting Zhang, Xuerui Wang, Peng Fu, Yang Wang.* Catalytic asymmetric synthesis of 3,4′-piperidinoyl spirooxindoles via [3+3] annulation of 3‑aminobenzofurans and isatin-derived enals. J. Org. Chem. 2024, 89, 5170. 10. Lesong Li, Xia Wang, Yang Wang.* Construction of spiro[pyrrolidine-azlactone] via [2+3] cycloaddition of alkylidene azlactone with trifluoromethylated imine J. Org. Chem. 2024, 89, 17824. 11. Xinyu Zhang, Yuan Pan, Tao Liu, Yang Wang.* Synthesis of 4‑aryl-1,3,4-benzotriazepinones from isatoic anhydrides and hydrazonyl chlorides. J. Org. Chem. 2023, 88, 7504. 12. Hao Dong, Yongxing Zhang, Xiaochen Tian, Ruochen Pang, Weiwu Ren, Yang Wang.* Catalyst-free and oxidant-free tandem aza-Mannich/cyclization/aromatization of C,N-cyclic azomethine imines with enamides: facile synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. Green. Chem. 2022, 24, 5508. (Cover Page) 13. Lesong Li, Tao Liu, Xiaoli Zhang, Xiaohan Hou, Hao Dong, Xiaoyang Li, Weiwu Ren, Yang Wang.* Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: facile synthesis of isoquinoline-fused spirocycles. Green Synth. Catal. 2022, 2, 69. 14. Fengbiao Luo, Hao Dong, Weiwu Ren, Yang Wang.* Organocatalytic asymmetric synthesis of tetrahydroquinolines from ortho-aminophenyl para-quinone methides. Org. Lett. 2022, 24, 7727. 15. Yuan Pan, Weiwu Ren, Zhanhao Zhang, Fengbiao Luo, Xiaohan Hou, Xiaoyang Li, Yun-Fang Yang, Yang Wang.* Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers. Org. Chem. Front. 2022, 9, 3697. 16. Xiaochen Tian, Yongxing Zhang, Hao Dong, Weiwu Ren, Yang Wang.* Asymmetric α‑regioselective [3+2] annulation of Morita−Baylis−Hillman carbonates: construction of three contiguous stereocenters with vicinal quaternary carbon centers. J. Org. Chem. 2022, 87, 9593. 17. Xiaochen Tian, Yongxing Zhang, Weiwu Ren, Yang Wang.* Synthesis of functionalized 3,2'-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and 3-chlorooxindoles. Org. Chem. Front. 2022, 9, 615. (Cover Page) 18. Michael Meanwell, Steven M. Silverman, Johannes Lehmann, Bharanishashank Adluri, Yang Wang, Ryan Cohen, Louis-Charles Campeau, Robert Britton.* A short de novo synthesis of nucleoside analogs. Science 2020, 369, 725. 19. Yang Wang,* Wen-Xiong Zhang, Zhenfeng Xi. Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction. Chem. Soc. Rev. 2020, 49, 5810. 20. Yang Wang, Qian Wang, Jieping Zhu.* Organocatalytic nucleophilic addition of hydrazones to imines: synthesis of enantioenriched vicinal diamines. Angew. Chem. Int. Ed. 2017, 56, 5612. 21. Yang Wang, Yue Chi, Wen-Xiong Zhang,* Zhenfeng Xi.* Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C–N and C(sp3)-H bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides. J. Am. Chem. Soc. 2012, 134, 2926. 22. Yang Wang, Wen-Xiong Zhang,* Zitao Wang, Zhenfeng Xi.* Procedure-controlled selective synthesis of 5-acyl-2-iminothiazolines and their selenium and tellurium derivatives by convergent tandem annulation. Angew. Chem., Int. Ed. 2011, 50, 8122. 二、博士研究生招生要求 1. 具有有机合成或者药物合成等相关背景。 2. 具有一定的有机化学理论基础和实验操作技能。 3. 在有机化学或者药物化学领域发表过SCI论文。 欢迎有意向的同学发送个人简历、科研论文等相关材料至电子邮箱wangyang@ouc.edu.cn |
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