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p300 null MSI+ cancer cell lines that re-express exogenous p300 showed slower growth and a more flattened morphology. Õâ¾ä»°ÊÇʲôÒâ˼°¡£¿ÔÚÏߵȣ¬ÇëÎð»úÒë¡£ ¸Ã¾äËùÔÚµÄÎÄ×Ö»·¾³ÊÇ£º The role of p300 and CBP in cancer is under debate. Some studies indicate a role as tumor suppressors, yet other studies suggest a role as tumor promoters. It has been reported that p300 behaves as a classical tumor suppressor gene. Another study reported that the p300 gene and the CBP gene are mutated in >85% of micro-satellite instable (MSI)+ colon cancer cell lines and primary tumors. p300 null MSI+ cancer cell lines that re-express exogenous p300 showed slower growth and a more flattened morphology. [ Last edited by gundnir on 2009-11-1 at 01:38 ] |
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onlliu
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