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身体健康，心情愉悦，简单幸福！

1楼2024-09-23 15:24:54

斜月彡星

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引用回帖:

2楼: Originally posted by brightfuture01 at 2024-09-23 16:30:04
应该都属于修饰，invAb可以检索出来是 inverted abasic deoxyribonucleotide的缩写。

文献参考：siRNA modification and delivery for drug development

https://www.cell.com/trends/molecular-medicine/abs ...

我以为是反向配对的，不过是脱氧核糖核酸？
那就是只是修饰？

身体健康，心情愉悦，简单幸福！

3楼2024-09-23 16:34:12

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brightfuture01

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【答案】应助回帖

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Alex0325: 金币+50, ★★★★★最佳答案, 谢谢 2024-09-24 08:50:23

应该都属于修饰，invAb可以检索出来是 inverted abasic deoxyribonucleotide的缩写。

文献参考：siRNA modification and delivery for drug development

https://www.cell.com/trends/mole ... 471-4914(22)00204-0

The world is a fine place and worth fighting for. I agree with the second part.

2楼2024-09-23 16:30:04

brightfuture01

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3楼: Originally posted by Alex0325 at 2024-09-23 16:34:12
我以为是反向配对的，不过是脱氧核糖核酸？
那就是只是修饰？...

是的，RNA不是容易降解么，为了提高in vivo使用的稳定性，做的各种修饰。

The stability can also be improved by the design of alternative modifications using other monomers, such as inosine and inverted abasic deoxyribonucleotide (invAb). Modified siRNAs achieve....

我没有这篇文章的权限，你可以看看原文的具体表述。

The world is a fine place and worth fighting for. I agree with the second part.

4楼2024-09-23 16:38:49

brightfuture01

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另外，可以看看Oligo合成厂家的介绍。

https://www.genelink.com/newsite/products/modoligosINFO.asp

Inverted 2'O methyl A (reverse linkage) [Inv-mA] 27-6447A $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl C (reverse linkage) [Inv-mC] 27-6447C $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl G (reverse linkage) [Inv-mG] 27-6447G $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl mixed bases (reverse linkage) [Inv-mN] 27-6447N $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl U (reverse linkage) [Inv-mU] 27-6447U $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted Abasic Site (dSpacer abasic furan) [iB] 26-6448 $200.00 $200.00 $255.00 $321.00 $1,147.50 $1,582.00 $1,809.00
Inverted dA (reverse linkage) [Inv-dA] 26-6551 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dC (reverse linkage) [Inv-dC] 26-6552 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dG (reverse linkage) [Inv-dG] 26-6553 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dT (reverse linkage) [Inv-dT] 26-6554 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted rA (reverse linkage) [Inv-rA] 27-6441 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rC (reverse linkage) [Inv-rC] 27-6442 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rG (reverse linkage) [Inv-rG] 27-6443 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rU (reverse linkage) [Inv-rU] 27-6444 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00

The world is a fine place and worth fighting for. I agree with the second part.

5楼2024-09-23 16:44:18