【答案】应助回帖

» 猜你喜欢

为什么蛋白质氨基酸测定大家都测17种? 已经有5人回复
《灰分记：我与坩埚的“灰烬”之恋》已经有3人回复
化学工程及工业化学论文润色/翻译怎么收费? 已经有236人回复
求助食品检验工（基础知识），中国劳动社会出版社电子版已经有5人回复
胶体几丁质的结晶度？已经有0人回复
诚挚招收全日制博士！！！中国农业科学院麻类研究所谭志坚研究员课题组招收博士已经有2人回复
三甲基羟乙基丙二胺的合成路线已经有5人回复

身体健康，心情愉悦，简单幸福！

1楼2024-09-23 15:24:54

brightfuture01

木虫之王 (文坛精英)

我爱打老虎

MolEPI: 14
应助: 24 (小学生)
贵宾: 1.2
金币: 113944
散金: 1526
红花: 224
沙发: 1
帖子: 28917
在线: 3664.2小时
虫号: 464575
注册: 2007-11-21
性别: GG
专业: 神经生物学

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
Alex0325: 金币+50, ★★★★★最佳答案, 谢谢 2024-09-24 08:50:23

应该都属于修饰，invAb可以检索出来是 inverted abasic deoxyribonucleotide的缩写。

文献参考：siRNA modification and delivery for drug development

https://www.cell.com/trends/mole ... 471-4914(22)00204-0

The world is a fine place and worth fighting for. I agree with the second part.

2楼2024-09-23 16:30:04

斜月彡星

主管区长 (文学泰斗)

噢，不是烟鬼丶

专家经验: +239
应助: 1001 (博后)
贵宾: 14.784
金币: 1258730
散金: 16399
红花: 2055
沙发: 8
帖子: 155231
在线: 6452小时
虫号: 1316494
注册: 2011-06-06
性别: GG
专业: 肿瘤免疫
管辖: 文献求助区

引用回帖:

2楼: Originally posted by brightfuture01 at 2024-09-23 16:30:04
应该都属于修饰，invAb可以检索出来是 inverted abasic deoxyribonucleotide的缩写。

文献参考：siRNA modification and delivery for drug development

https://www.cell.com/trends/molecular-medicine/abs ...

我以为是反向配对的，不过是脱氧核糖核酸？
那就是只是修饰？

身体健康，心情愉悦，简单幸福！

3楼2024-09-23 16:34:12

brightfuture01

木虫之王 (文坛精英)

我爱打老虎

MolEPI: 14
应助: 24 (小学生)
贵宾: 1.2
金币: 113944
散金: 1526
红花: 224
沙发: 1
帖子: 28917
在线: 3664.2小时
虫号: 464575
注册: 2007-11-21
性别: GG
专业: 神经生物学

引用回帖:

3楼: Originally posted by Alex0325 at 2024-09-23 16:34:12
我以为是反向配对的，不过是脱氧核糖核酸？
那就是只是修饰？...

是的，RNA不是容易降解么，为了提高in vivo使用的稳定性，做的各种修饰。

The stability can also be improved by the design of alternative modifications using other monomers, such as inosine and inverted abasic deoxyribonucleotide (invAb). Modified siRNAs achieve....

我没有这篇文章的权限，你可以看看原文的具体表述。

The world is a fine place and worth fighting for. I agree with the second part.

4楼2024-09-23 16:38:49

brightfuture01

木虫之王 (文坛精英)

我爱打老虎

MolEPI: 14
应助: 24 (小学生)
贵宾: 1.2
金币: 113944
散金: 1526
红花: 224
沙发: 1
帖子: 28917
在线: 3664.2小时
虫号: 464575
注册: 2007-11-21
性别: GG
专业: 神经生物学

另外，可以看看Oligo合成厂家的介绍。

https://www.genelink.com/newsite/products/modoligosINFO.asp

Inverted 2'O methyl A (reverse linkage) [Inv-mA] 27-6447A $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl C (reverse linkage) [Inv-mC] 27-6447C $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl G (reverse linkage) [Inv-mG] 27-6447G $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl mixed bases (reverse linkage) [Inv-mN] 27-6447N $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted 2'O methyl U (reverse linkage) [Inv-mU] 27-6447U $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00
Inverted Abasic Site (dSpacer abasic furan) [iB] 26-6448 $200.00 $200.00 $255.00 $321.00 $1,147.50 $1,582.00 $1,809.00
Inverted dA (reverse linkage) [Inv-dA] 26-6551 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dC (reverse linkage) [Inv-dC] 26-6552 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dG (reverse linkage) [Inv-dG] 26-6553 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted dT (reverse linkage) [Inv-dT] 26-6554 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00
Inverted rA (reverse linkage) [Inv-rA] 27-6441 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rC (reverse linkage) [Inv-rC] 27-6442 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rG (reverse linkage) [Inv-rG] 27-6443 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00
Inverted rU (reverse linkage) [Inv-rU] 27-6444 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00

The world is a fine place and worth fighting for. I agree with the second part.

5楼2024-09-23 16:44:18