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专业: 免疫学研究新技术与新方法

[交流] 大家帮忙看一下二审意见.几个疑问请高手指点,谢谢

文章经过初审让大修.大修后经二审,意见如下
Reviewer #1: The paper has been clearly improved. However, the effects of bFGF gene silencing on glioma cell proliferation remain rather low.
Minor point: the authors should label the x-axis of the diagram in Fig. 4.

Reviewer #2: The authors have responded to most of the reviewers comments, but serious reservations remain.
The biggest issue is that the effects observed are fairly modest, and do not provide convincing evidence that this approach will lead anywhere in glioma therapy.
This could potentially be rescued by survival studies, or combinations with chemotherapeutics as suggested in the previous round of comments. The use of glioma stem-like cells may also help, as these may be more responsive to this approach.

MINOR POINTS
1. the cell line should be referred to as LN229 rather than L229.
2. Exposure for the scratch assay shown in figure 2 is very uneven.

现有个疑问.请高指点一下评阅人的这几句话用回答吗

Reviewer #1: The paper has been clearly improved. However, the effects of bFGF gene silencing on glioma cell proliferation remain rather low.

Reviewer #2: The authors have responded to most of the reviewers comments, but serious reservations remain.
The biggest issue is that the effects observed are fairly modest, and do not provide convincing evidence that this approach will lead anywhere in glioma therapy.

This could potentially be rescued by survival studies, or combinations with chemotherapeutics as suggested in the previous round of comments. The use of glioma stem-like cells may also help, as these may be more responsive to this approach.

还是只回答下面的几点就可以
Minor point: the authors should label the x-axis of the diagram in Fig. 4.
MINOR POINTS
1. the cell line should be referred to as LN229 rather than L229.
2. Exposure for the scratch assay shown in figure 2 is very uneven.

高手指点.谢谢

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