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Diane J. Burgess
Ph.D.
Board of Trustees Distinguished Professor
Professor of Pharmaceutics
University of Connecticut
School of Pharmacy
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Diane J. Burgess
Ph.D.
Board of Trustees Distinguished Professor
Professor of Pharmaceutics

University of Connecticut
School of Pharmacy, Room 432
69 North Eagleville Road, Unit 3092
Storrs, Connecticut 06269-3092

Phone: (860) 486-3760
Fax: (860) 486-2076
E-Mail: d.burgess@uconn.edu

Educational Background
◊  Postdoctural Research, Universities of Amsterdam, Nottingham, and North Carolina   
◊ Ph.D., University of London, United Kingdom     
◊ B.Sc., University of Strathclyde, Glasgow, United Kingdom
     
Professional Accomplishments

Dr. Burgess was the recipient of the Outstanding Teacher of the Year Award (2005 and 1992).  She was the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is an AAPS fellow.  She was recently elected Vice President of the Controlled Release Society and will be the 2009-2010 President.  She is currently a member of the USP Biopharmaceuticals Expert committee and is a member of the USP Advisory Panel on Injectables.  Dr. Burgess was an editor for AAPSharmsci (1999-2005) and is editor of the Journal of Drug Delivery Science and Technology (2003-present) and serves on the editorial boards of: the Journal of Pharmacy and pharmacology (1997-present); the Journal of Microencapsulationi (1997-present); Crital Reviewers in Therapeutic Drug Carrier Systems (2004-present); the International Journal of Pharmaceutics (2004-present); and the Journal of Diabetes Science and Technology (2006-present).  In 2001 she underook a sabbatical leave at the Office of Testing and Research at CDER, FDA.  She consults for pharmaceutical, food, cosmetic and other engineering industries on issues related to dispersed systems, in vitro release testing, IVIVC, interfacial chemistry and particle size analysis.

Professional Interests

Dr. Burgess runs a multidisciplinary laboratory.  Research efforts focus on drug delivery systems, in particular, nonoparticles, microspheres, emulsions, liposomes, hydrogels, and novel coatings for implantable devises as well as interfacial chemistry.  Research interests include small molecule drugs, proteins, peptides and DNA therapeutics.  Together with faculty in Chemistry (Dr. Fotios Papadimitrakopoulos) and Electrical Engineering (Dr. Faquir Jain), Dr. Burgess is developing a miniaturized, implantable biosensor for metabalic monitoring.  The team is developing an implantable coating to control tissue response to implantable devices.  Drs. Burgess and Papidimitrakopoulos are using quantum dots to investigate intracellular traficking of DNA therapeutics and vectors.  Dr. Burgess' group is developing in vitro performance tests for controlled release parenterals products and has collaborations with both the Food and Drug Association (FDA) and the United States Pharmacopeia (USP).  This work includes evaluation of in vitro and in vivo correlation (IVIVC) of controlled release parenterals and development of appropriate in vitro release testing methods.  Other important research areas are investigation of both nanoparticle and emulsion stability using a variety interfacial techniques and particle size analysis.

Selected Recent Publications (out of over 100 publications)  
1.  B.S. Zolnik, and D.J. Burgess*.  Evaluation of In vivo - In vitro Release of Dexamethasome from PLGA Microspheres. J. Controlled Release 2008 (127) 137-145.
   
2.  U. Bhardwaj, R. Sura, F. Papadimitrakopoulos, and D.J. Burgess*.  Controlling Acute Inflammation with fast-releasing dexamethasone PLGA microsphere/PVA hydrogel composites for implantable devices.  Journal of Diabetes Science and Technology 2007, 1(1) 8-17.
   
3.  S.D. Patil, F. Papidimitrakopoulos, and D.J. Burgess*.  Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis. J. Controlled Release 2007, 117(1) 68-79.
   
4.  C. Srinivasan, J. Lee, F. Papadimitrakopoulos, L.K. Silbart, M.H. Zhao and D.J. Burgess*.  Labeling and intracellular tracking of functionally active plasmid DNA with semiconductor quantum dots.  Molecular Therapy 2006, 14(2) 192-201.
   
5.  S.D. Patil, D.G. Rhodes, and D.J. Burgess*.  Bio-physical characterization of a novel anionic liposomal delivery system.  Biochimica et Biophysica Acta. 2005; 1711(1):1-11.
  Top ten most downloaded articles of 2005 in BBA.
   
6.  S.D. Patil, D.G. Rhodes and D.J. Burgess*.  DNA-based therapeutics and their delivery systems: A comprehensive review.  The AAPS J. 2005;7(1):article 9.
  2007 Outstanding Manuscript Award, The AAPS Journal
   
7.  S.D. Patil, D.G. Rhodes and D.J. Burgess*.  Anionic liposomal delivery system for DNA transfection.  The AAPS J. 2004:6(4);article 29.
   
8.  J. Jiao and D.J. Burgess*.  Ostwald ripening of water-in-hydrocarbon emulsions.  J. Coll. Interface Sci. 2003;264(2):506-516.
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