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dk278960

新虫 (小有名气)

[交流] 德国弗莱堡大学博士招生 超分子化学(岗位制,有工资)

德国 University of Freiburg, Dr. Charalampos Pappas 博士招生 (ERC 欧洲研究委员会资金支持)

超分子化学,动态自组装,非平衡态,液液分离,系统化学,多肽化学

ERC-funded PhD Position: Building Chemical Reaction Networks with Structural Elements around Activated Amino Acids
Starting date: 01/09/2024 or earliest possible time

Project Description

Phosphates and phosphate esters play essential roles in various biological functions, including encoding genetic information, regulating signal transduction mechanisms, and providing chemical energy. In particular, biochemical phosphates activate transient assemblies by incorporating structural and recognition elements. Beyond phosphoric anhydrides, other biological fuels like creatine, carbamoyl phosphate, and nicotinamide adenine dinucleotides (NADH/NADPH) drive selective metabolic processes.

Recent research demonstrated that amino acyl phosphate esters can covalently bind to substrates, influencing structures in assembly processes. The structural elements around activated moieties encode properties in transient structures.

Project Aims:

Synthesize short peptide sequences of aminoacyl phosphate esters.
Achieve selection in mixtures containing different types of activated amino acids.
Characterize these systems in terms of composition, nanoscale architecture, and supramolecular interactions.
The project will explore the structural behavior of aminoacyl phosphate esters by varying amino acid side chains, N-terminus sequences, and phosphate esters. These variations will direct different pathways for forming and destroying assemblies, impacting phosphate-driven supramolecular systems chemistry.

Relevant Publications

Dai, K.; Pol, M.; Saile, L.; Sharma, A.; Liu, B.; Thomann, R.; Trefs, J.; Qiu, D.; Moser, S.; Wiesler, S.; Balzer, B.; Hugel, T.; Jessen, H.; Pappas, C. G., Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes. J. Am. Chem. Soc. 145, 48, 26086–26094.
Pol, M.; Dai, K.; Thomann, R.; Moser, Pappas, C. G., Guiding Transient Peptide Assemblies with Structural Elements Around Abiotic Phosphate Fuels. Angew. Chem. Int. Ed., 2024, e202404360.
Candidate Profile

We seek a highly motivated PhD candidate with interdisciplinary competences ranging from organic and analytical chemistry to supramolecular and systems chemistry.

Requirements:

Master’s degree with outstanding grades in chemistry, polymer science, or functional materials.
Strong willingness to work interdisciplinarily.
Previous experience in solid and solution phase peptide synthesis, dynamic covalent chemistry, or spectroscopic techniques is appreciated but not required.
Strong competences in scientific presentations and writing (English).
Team skills for a creative, productive, and dynamic research team.
Application Instructions

Please submit the following documents in English by 01/08/2024:

Motivation Letter (up to 1,500 words): Detail why you are interested in this specific project, potential ideas you could develop, and how your previous research qualifies you.
Curriculum Vitae: Include a list of publications (if applicable).
Certified Copies of University Degrees: Include grades (BA and MA certificate/Diploma certificate and transcript). 如果还没有获得可以稍晚提交
Short Summary of Master’s Thesis (up to 1,000 words).
Two Reference Letters.
Contact

Send your application to:
Charalampos Pappas
charalampos.pappas@livmats.uni-freiburg.de

More Information about Our Research:
https://pappasresearchgroup.com/
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dk278960

新虫 (小有名气)

引用回帖:
2楼: Originally posted by 蝶影 at 2024-07-22 14:20:25
需要语言成绩吗

不需要,只要能沟通顺畅就行
3楼2024-07-22 22:39:32
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蝶影

银虫 (著名写手)

2楼2024-07-22 14:20:25
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IMPolysLY

新虫 (初入文坛)

4楼2025-03-13 04:52:09
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IMPolysLY

新虫 (初入文坛)

师兄能去你们组做HiWI或者实习吗?我是弗莱堡大学高分子硕士
发自小木虫手机客户端
5楼2025-03-13 04:52:45
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