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2241586-20-7的Scifinder合成路线和相关专利
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链接: https://pan.baidu.com/s/1v2Bt-ZYLE7gaUbs4O2TK-w 提取码: auij 复制这段内容后打开百度网盘手机App，操作更方便哦 该物质所以文献就1篇中文专利 Preparation of [(isoxazol-4-yl)methoxy]spiro compounds useful for the treatment of FXR mediated diseases By: Li, Xiaochuan China, CN108218852 A 2018-06-29 | Language: Chinese, Database: CAplus The invention relates to spiro compounds of formula I, method for their preparation and their use for the treatment of FXR mediated diseases. Compounds of formula I, where R1 is (un)substituted 5- to 10-membered (hetero)aryl; R2 is H, (halo)C1-3alkyl and C3-6cycloalkyl; Z is (un)substituted 5- to 10-membered (hetero)aryl; A is N, CH and C(OH); D, E, F, G are independently (CH3)1-4, and their pharmaceutically acceptable salts, solvates, N-oxides, etc., are claimed. Example compound II was prepared via a multistep procedure (procedure given). The spiro compound can effectively treat farnesol X r… |
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