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mingming21

新虫 (初入文坛)

应助: 1 (幼儿园)
金币: 45.5
帖子: 28
在线: 6.4小时
虫号: 31078473

[交流] 俄亥俄大学医学院生物医学系骨性关节炎实验室博士后招聘

俄亥俄大学医学院Dr. Zhu实验室计划招收博士后1名，2024年入职。主要研究方向为生长激素对骨性关节炎的影响和相关机制。

基本要求：
1. 已取得或者即将取得生物学、医学生物学等相关专业的博士学位。
2. 具备做科学研究的热情，独立研究能力和团体合作意识。
3. 近三年内在相关领域权威期刊以第一作者身份发表过研究论文优先考虑。
4. 有生物信息学，代谢生物学背景及转基因小鼠管理经验者优先考虑。

待遇：以NIH博后标准为基础，为优秀博士后提供额外的津贴。

研究工作简介：
Growth Hormone (GH) is an FDA approved drug to treat certain diseases such as growth hormone deficiency (GHD). Additionally, GH secretion decreases over time, causing some older adults to consider the use of GH replacement as a means to counteract aging related conditions. However, over-production or prolonged usage of GH has been reported to have many side effects including joint degeneration and joint pain. Identifying the mechanisms by which GH causes joint cell dysfunction during aging could inform effective interventions and therapeutic strategies that reduce the incidence and impact of OA. Our preliminary studies have shown that over-expression of GH gene in mice predispose mice into progressive joint degeneration, while blocking GH action through systemic GH receptor disruption protect mice from developing OA. We showed that GH robustly altered the metabolism of cells (i.e, chondrocytes) in cartilage (Arthritis & Rheumatology, 2023). Yet, it is still unknown if blocking GH’s action specifically on cartilage tissue would be protective. In this project, several genetically modified mouse models, in vivo and in vitro metabolic profiling methods will be leveraged to determine the effects of manipulating GH signaling on chondrocyte cellular metabolism. Last but not least, a unique mouse model that was used for discovery of Pegvisomant, an FDA approved drug for treating acromegaly, will be used to test if blocking GH is beneficial for joint health.

实验室网站：
https://ou.theopenscholar.com/zhu-shouan/
合作导师介绍：
https://www.researchgate.net/profile/Shouan-Zhu-2
https://scholar.google.com/citations?user=5DPLUl4AAAAJ

目前课题组经费充足，感兴趣者请将英文简历发送至zhus1@ohio.edu.

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