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[资源] 【分享】Understanding Drug Release and Absorption Mechanisms【已搜无重复】

Understanding Drug Release and Absorption Mechanisms：A PHYSICAL and
MATHEMATICAL APPROACH

Dedication
Mario Grassi
dedicates this book to his parents
Elvira and Giancarlo, his wife Francesca, and
his sons Lucia and Giacomo
Gabriele Grassi
dedicates this book to his
parents Elvira and Giancarlo who taught him
how to live, to Chiara, his shining star of the morning,
and to Roberta, the constant support of his life

Table of Contents
Chapter 1
Mathematical Modeling................................................................................... 1
1.1 Introduction............................................................................................. 1
1.2 Model Building....................................................................................... 3
1.2.1 Model Building: An Example .................................................... 8
1.3 Model Fitting ........................................................................................ 11
1.3.1 Chi-Square Fitting: Straight Line ............................................. 19
1.3.2 Chi-Square Fitting: General Case............................................. 21
1.3.3 Robust Fitting ........................................................................... 22
1.4 Models Comparison.............................................................................. 25
1.5 Conclusions........................................................................................... 26
References...................................................................................................... 26
Chapter 2
Part 1 Gastrointestinal Tract....................................................................... 29
2.1 Macro- and Microscopic Anatomy of the
Gastrointestinal Tract ........................................................................... 29
2.1.1 The Stomach ............................................................................. 29
2.1.2 The Small Intestine................................................................... 30
2.1.3 The Colon ................................................................................. 32
2.1.4 Absorptive Cells ....................................................................... 32
2.1.5 Tight Junctions.......................................................................... 33
2.1.6 Cellular Membrane ................................................................... 34
2.2 Intestinal Absorption ............................................................................ 35
2.2.1 Positive and Negative Forces ................................................... 35
2.2.2 Drug Absorption Pathways....................................................... 36
2.2.3 Absorption in GI Diseases........................................................ 38
2.2.4 Models of Intestinal Absorption............................................... 40
2.3 Human and Animal GI Tract: A Comparison ..................................... 42
2.3.1 Anatomy.................................................................................... 42
2.3.1.1 The Stomach .............................................................. 42
2.3.1.2 The Small Intestine.................................................... 43
2.3.1.3 The Colon .................................................................. 43
2.3.2 Physiology................................................................................. 45
2.3.2.1 pH and Bile Fluid ...................................................... 45
2.3.2.2 Microflora and Mucin ............................................... 49

很想把封面传上去给大家看的。可惜不会插入图片，哪位虫友帮帮我，谢谢啦。
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