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Understanding Drug Release and Absorption Mechanisms£ºA PHYSICAL and MATHEMATICAL APPROACH Dedication Mario Grassi dedicates this book to his parents Elvira and Giancarlo, his wife Francesca, and his sons Lucia and Giacomo Gabriele Grassi dedicates this book to his parents Elvira and Giancarlo who taught him how to live, to Chiara, his shining star of the morning, and to Roberta, the constant support of his life Table of Contents Chapter 1 Mathematical Modeling................................................................................... 1 1.1 Introduction............................................................................................. 1 1.2 Model Building....................................................................................... 3 1.2.1 Model Building: An Example .................................................... 8 1.3 Model Fitting ........................................................................................ 11 1.3.1 Chi-Square Fitting: Straight Line ............................................. 19 1.3.2 Chi-Square Fitting: General Case............................................. 21 1.3.3 Robust Fitting ........................................................................... 22 1.4 Models Comparison.............................................................................. 25 1.5 Conclusions........................................................................................... 26 References...................................................................................................... 26 Chapter 2 Part 1 Gastrointestinal Tract....................................................................... 29 2.1 Macro- and Microscopic Anatomy of the Gastrointestinal Tract ........................................................................... 29 2.1.1 The Stomach ............................................................................. 29 2.1.2 The Small Intestine................................................................... 30 2.1.3 The Colon ................................................................................. 32 2.1.4 Absorptive Cells ....................................................................... 32 2.1.5 Tight Junctions.......................................................................... 33 2.1.6 Cellular Membrane ................................................................... 34 2.2 Intestinal Absorption ............................................................................ 35 2.2.1 Positive and Negative Forces ................................................... 35 2.2.2 Drug Absorption Pathways....................................................... 36 2.2.3 Absorption in GI Diseases........................................................ 38 2.2.4 Models of Intestinal Absorption............................................... 40 2.3 Human and Animal GI Tract: A Comparison ..................................... 42 2.3.1 Anatomy.................................................................................... 42 2.3.1.1 The Stomach .............................................................. 42 2.3.1.2 The Small Intestine.................................................... 43 2.3.1.3 The Colon .................................................................. 43 2.3.2 Physiology................................................................................. 45 2.3.2.1 pH and Bile Fluid ...................................................... 45 2.3.2.2 Microflora and Mucin ............................................... 49 ºÜÏë°Ñ·âÃæ´«ÉÏÈ¥¸ø´ó¼Ò¿´µÄ¡£¿Éϧ²»»á²åÈëͼƬ£¬ÄÄλ³æÓѰï°ïÎÒ£¬Ð»Ð»À²¡£ ÄÉÃ×ÅÌÏÂÔØÁ´½Ó£º http://www.namipan.com/d/Underst ... e4fbcb76372f6d46200 |
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