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dreamer2001ly木虫 (正式写手)
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[求助]
麻烦帮忙查一下这篇文献在web of sci上收录了没有, 有没有WOS号？
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Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk. Chen L, Wang Y, Wang Y, Huang S, Wu Z, He J, Zhong W, Zhao B, Ma G, Li Y. Pharmgenomics Pers Med. 2022 May 11;15:477-485. doi: 10.2147/PGPM.S364648. eCollection 2022. PMID: 35586478 Free PMC article. 如上，谢谢！ |
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【答案】应助回帖
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dreamer2001ly: 金币+5, ★★★★★最佳答案 2022-07-05 12:55:55
sunshan4379: LS-EPI+1, 感谢应助! 2022-07-10 15:17:00
dreamer2001ly: 金币+5, ★★★★★最佳答案 2022-07-05 12:55:55
sunshan4379: LS-EPI+1, 感谢应助! 2022-07-10 15:17:00
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Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk. 作者: Chen, Linfa; Wang, Ying; Wang, Yajun; Huang, Shaoting; Wu, Zhaochun; He, Jiawen; Zhong, Wangtao; Zhao, Bin; Ma, Guoda; Li, You 查看 Web of Science ResearcherID 和 ORCID (由 Clarivate 提供) Pharmacogenomics and personalized medicine 卷15 页477-485 DOI10.2147/PGPM.S364648 出版时间2022-05-11 已索引2022-05-20 文献类型Journal Article 摘要 Background: Emerging evidences suggest that the angiotensin receptor type 1 (AT1R) contributes heavily to the pathogenesis of atherosclerotic cerebral infarction (ACI). Herein, we examined a potential link between AT1R gene polymorphisms and ACI risk among a Southern Han Chinese population. Methods: The rs3772616, rs275645, and rs377262 AT1R polymorphisms were genotyped in 689 ACI patients and 712 healthy controls, using the iMLDR-TM assay. Results: The genotypic and allelic frequencies of AT1R rs3772616 differed tremendously between ACI patients and healthy controls, and the rs3772616 T allele is a risk allele for ACI. However, the rs275645 and rs377262 allelic and genotypic frequency distributions were comparable between ACI patients and controls. In addition, the G-T-T haplotype was linked to an enhanced risk of ACI. We, next, classified our study subjects based on environmental factors and revealed that the rs3772616 T allele was strongly associated with an elevated ACI risk in males, hypertensive individuals, and those over 65 years old. In addition, we observed a marked link between the rs3772616 T allele and enhanced AT1R levels. Conclusion: Based on our research, there is a strong correlation between the AT1R rs3772616 polymorphism and enhanced ACI risk. Hence, the AT1R rs3772616 polymorphism can serve as a potential therapeutic target and bioindicator for ACI development. © 2022 Chen et al. 利益冲突声明 The authors declare no actual or potential conflicts of interest in this work. 关键词 关键词列表angiotensin receptor type 1atherosclerotic cerebral infarctioncase-controlpolymorphism 作者信息 地址 Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China. Department of Neurology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, 516002, People's Republic of China. Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China. Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Shunde, Guangdong, 528300, People's Republic of China. Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China. 文献信息 语种English 媒介Print 入藏号MEDLINE:35586478 PubMed ID35586478 ISSN1178-7066 电子出版2022-05-11 NLM 唯一 ID101514107 国家/地区New Zealand 修订日期2022-05-20 其他信息 记录所有者NLM 状态PubMed-not-MEDLINE |
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