| 查看: 476 | 回复: 3 | |||
| 当前主题已经存档。 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
windli木虫 (职业作家)
|
[交流]
【求助】求欧洲药典6.5的tenoxicam
|
||
|
求欧洲药典6.5的tenoxicam 哪位弟兄能帮帮忙 |
回复此楼» 猜你喜欢
南方医科大学珠江医院肖计生课题组招收博士生 （2026年入学）
已经有2人回复
-
349药学专硕105500求调剂
已经有0人回复
-
药理学论文润色/翻译怎么收费?
已经有285人回复
-
求调剂
已经有1人回复
-
298求调剂一志愿中海洋
已经有3人回复
-
广西医科大学基础医学院自身免疫病课题组招收基础医学相关专业的调剂研究生
已经有2人回复
-
药学调剂申请自荐信，一志愿中南大学
已经有1人回复
-
药学349专硕求调剂
已经有1人回复
-
《左乙拉西坦注射液制备工艺研究、质量控制和稳定性研究》下载
已经有1人回复
-
药学专硕申博
已经有3人回复
-
105500药学求调剂，一志愿山东大学药学，348分
已经有1人回复
windli
木虫 (职业作家)
- 应助: 7 (幼儿园)
- 金币: 3607.3
- 散金: 32
- 红花: 24
- 帖子: 3402
- 在线: 365.3小时
- 虫号: 154709
- 注册: 2006-01-03
- 专业: 元素有机化学
3楼2009-09-09 09:22:04
ienjoysun
银虫 (著名写手)
- 应助: 5 (幼儿园)
- 金币: 4739.9
- 散金: 83
- 红花: 4
- 帖子: 2441
- 在线: 207.2小时
- 虫号: 494917
- 注册: 2008-01-14
- 专业: 药物毒理
EP
★ ★ ★ ★ ★ ★
小木虫(金币+0.5):给个红包，谢谢回帖交流
windli(金币+5,VIP+0):谢谢帮忙 9-9 09:18
小木虫(金币+0.5):给个红包，谢谢回帖交流
windli(金币+5,VIP+0):谢谢帮忙 9-9 09:18
|
(Ph Eur monograph 1156) [bitmap] C13H11N3O4S2 337.4 59804-37-4 Action and use Anti-inflammatory; analgesic. Preparations Tenoxicam Injection Tenoxicam Tablets Ph Eur DEFINITION Tenoxicam contains not less than 99.0 per cent and not more than the equivalent of 101.0 per cent of 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e]1,2-thiazine-3-carboxamide 1,1-dioxide, calculated with reference to the anhydrous substance. CHARACTERS A yellow, crystalline powder, practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in ethanol. It dissolves in solutions of acids and alkalis. It shows polymorphism. IDENTIFICATION Examine by infrared absorption spectrophotometry (2.2.24), comparing with the spectrum obtained with tenoxicam CRS. If the spectra obtained in the solid state show differences, dissolve the substance to be examined and the reference substance separately in the minimum quantity of methylene chloride R, evaporate to dryness on a water-bath and record new spectra using the residues. TESTS Appearance of solution Dissolve 0.10 g in 20 ml of methylene chloride R. The solution is clear (2.2.1). Related substances Examine by thin-layer chromatography (2.2.27), using silica gel GF254 R as the coating substance. Test solution Dissolve 0.4 g in a mixture of 4 volumes of concentrated ammonia R and 96 volumes of methanol R and dilute to 5 ml with the same mixture of solvents. Reference solution (a) Dilute 1 ml of the test solution to 20 ml with a mixture of 4 volumes of concentrated ammonia R and 96 volumes of methanol R. Dilute 1 ml of the solution to 20 ml with the same mixture of solvents. Reference solution (b) Dissolve 20 mg of tenoxicam CRS and 20 mg of salicylic acid CRS in a mixture of 4 volumes of concentrated ammonia R and 96 volumes of methanol R and dilute to 5 ml with the same mixture of solvents. Reference solution (c) Dissolve 20 mg of pyridin-2-amine R in a mixture of 4 volumes of concentrated ammonia R and 96 volumes of methanol R and dilute to 5 ml with the same mixture of solvents. Dilute 2 ml of the solution to 50 ml with the same mixture of solvents. Apply separately to the plate 10 µl of each solution. Develop over a path of 15 cm with a mixture of 5 volumes of anhydrous formic acid R, 5 volumes of methanol R, 20 volumes of acetone R and 70 volumes of methylene chloride R. Allow the plate to dry in air. Examine in ultraviolet light at 254 nm. Any spot corresponding to pyridin-2-amine in the chromatogram obtained with the test solution is not more intense than the spot in the chromatogram obtained with reference solution (c) (0.2 per cent). Any spot in the chromatogram obtained with the test solution apart from the principal spot and any spot corresponding to pyridin-2-amine, is not more intense than the spot in the chromatogram obtained with reference solution (a) (0.25 per cent). The test is not valid unless the chromatogram obtained with reference solution (b) shows two clearly separated spots. Heavy metals (2.4.8) 0.5 g complies with limit test C for heavy metals (20 ppm). Prepare the standard using 5 ml of lead standard solution (2 ppm Pb) R. Water (2.5.12) Not more than 0.5 per cent, determined on 1.000 g by the semi-micro determination of water. Sulphated ash (2.4.14) Not more than 0.1 per cent, determined on 1.0 g. ASSAY Dissolve 0.250 g in 5 ml of anhydrous formic acid R. Add 70 ml of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20). 1 ml of 0.1 M perchloric acid is equivalent to 33.74 mg of C13H11N3O4S2. STORAGE Store protected from light. IMPURITIES [bitmap] A. pyridin-2-amine, [bitmap] B. methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e]1,2-thiazine-3-carboxylate 1,1-dioxide. Ph Eur |
2楼2009-09-09 09:15:23
fdaedqm
木虫 (正式写手)
- 应助: 4 (幼儿园)
- 金币: 3276.8
- 散金: 18
- 红花: 3
- 帖子: 443
- 在线: 69.1小时
- 虫号: 310078
- 注册: 2006-12-23
- 性别: GG
- 专业: 药物化学
4楼2009-09-10 08:40:46
20