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godgoodstudy木虫 (小有名气)
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[交流]
博士招生[3+2] cycloaddition reaction
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joint supervision between university of rouen & university of florence phd: towards stereocontrolled s-cis and s-trans peptidic bond mimics by regiocontrolled [3+2] cycloaddition reactions. start : october 1st 2022 duration : 36 months missions : in the frame of the graduate school for research xl-chem (https://www.xlchem.fr/), a co-financed joint supervised position is available at umr 6014 cnrs cobra (rouen) and dipartimento di chimica ugo schiff (florence). the phd candidate will implement solid phase peptide synthesis (spps) compatible regiocontrolled [3+2] cycloaddition reactions to mimic either s-cis or s-trans conformation of the peptidic bond, and evaluated the biological activity of obtained polypeptidic scaffolds. activities - organic chemistry - spps - nmr, uv and mass analysis - biological evaluation of pseudopeptides activity - bibliography - research article writing - regular reports skills - master degree in organic synthesis or advanced molecular sciences - chemistry / biology interface context : joint supervision between pr. annamaria papini (florence) and pr. pierre-yves renard (rouen). first 18 months will take place in umr 6014 cnrs cobra (http://www.lab-cobra.fr/) at rouens university, and will be devoted to the implementation of spps compatible methods for the synthesis of diverse heteroaromatic derivatives through [3+2] cycloaddition methods, allowing to mimic either s-cis or s-trans conformation of the peptidic bond with. salary and working contract will be the usual french « contrat doctoral » (1520 � net wages). 18 next months will take place in the interdepartmental laboratory of peptide & protein chemistry & biology, dipartimento di chimica “ugo schiff“ (https://www.chim.unifi.it/) of the universitá degli studi di fierenze. the phd candidate will receive a 1200 � monthly grant to implement the [3+2] cycloaddition methods on spps to synthesize geometrically constrained biologically active polypeptides analogues, study by nmr their 3d conformation, and evaluate their biological activity. required documents : - vitae (1 page) - contact names - summary of research work (<3 pages) application pierre-yves renard: pierre-yves.renard@univ-rouen.fr anna maria papini: annamaria.papini@unifi.it |
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