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Reviewer(s)' Comments to Author: Reviewer: 1 Comments to the Author Dear Authors! I liked the article on the disclosure of the pathogenesis of preeclampsia XXXXXXX£¨ÎÒµÄÂÛÎÄÃû³Æ£©. The article was made at a high scientific level, many research methods were applied, blood plasma and placental tissue were studied. The article is written in understandable language. The advantages of the article include a detailed Discussion. It is important to note the fact, which was also noted in our studies, is an increase in the activity of oncosuppressor genes, against the background of an increase in genes associated with invasion (Nizyaeva NV, Kulikova GV, Nagovitsyna MN, Kan NE, Prozorovskaya KN, Shchegolev AI. Change in OncomicroRNA Expression in the Placenta during Preeclampsia. Bull Exp Biol Med. 2018 Oct; 165 (6): 793-797. Doi: 10.1007 / s10517-018-4267-7. Epub 2018 Oct 23 PMID: 30353329).Sample Text The results are described in detail, the connection with signaling pathways is presented. Some limitation should be considered studies carried out only on cell cultures, and not on experimental models. For some comments, it should be noted that the definition of the molecular profile associated with inflammation in the 2nd trimester of pregnancy is very variable and can increase starting from 12 weeks, reaching a peak at 16-17 weeks, and their decrease by 18-19 weeks. This is the difficulty of studying early terms, especially in cases of clinical trials in humans, when there is always a question with the comparison group.£¨ÕâÊÇÐèÒªÎÒ×öʵÑé²¹³äÊý¾ÝÄØ£¿»¹ÊǽâÊÍһϾÍÐУ¿ÎÒûÓÐÊÕ¼¯12 weeksµÄÑù±¾£¬Ã»°ì·¨²¹ÊµÑ飬½âÊÍÒ»ÏÂÐв»ÐУ¿£© I think this article is very interesting and can be published in the journal. Yours sincerely Reviewer: 2 Comments to the Author Preeclampsia is a leading cause of maternal and fetal/neonatal mortality and morbidity worldwide. Investigating the markers of the disease and their possible mechanism of action is important in order to reduce the risk of the disease. There is now an increasing list of markers of preeclampsia are being investigated. XX is one of them.  This is an interesting study presenting the mechanisms of involvement of XX in preeclampsia. However, I think presenting other biochemical markers such as sFlt-1, soluble endoglin, Papp-1, etc along with XX data from their patients would have strengthened their work. £¨Õâ¸öreviewerÌáµÄÖ¸±êÎÒµ¹ÊÇÄÜÁ¢Âí²¹Á½¸öELISAµÄÊý¾Ý£¬ºÄʱ²»³¤¡££© µÚÒ»¸öreviewerµÄ̬¶ÈÈÃÎұȽÏÃԻ󣬵½µ×ÊÇÈÃÎÒ²¹ÊµÑéÄØ£¬»¹ÊÇ¡­¡­¾ÍÊÇ˳×ì˵ÁËÒ»¾ä£¬Ò²Ã»ÏëÈÃÎÒ²¹ÊµÑéµÄ? ÒÔÇ°¶ÁÊéʱдÎÄÕ¶¼ÊÇÀÏ°åдÁËͶÁË£¬¸æËßÎÒÓÐûÓнÓÊÕ£¬×Ô¼ºÍêÈ«²»ÖªµÀÔõôºÍ±à¼­ÃÇ´ò½»µÀ¡£

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