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liruiguang金虫 (正式写手)
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[交流]
【求助】求帮忙翻译一篇英文文献（如果金币不够我会陆续的补上）
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http://d.namipan.com/d/a2f247ec2 ... 0b946d20fc206c20c00 论文不是很难 只是有些专业词和公式 是有关奶蛋白和药物方面的 非常感谢大家 [ Last edited by liruiguang on 2009-8-23 at 13:15 ] |
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2楼2009-08-23 22:10:03
liruiguang
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3楼2009-08-24 09:10:29
4楼2009-08-24 09:30:56
liruiguang
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Unbound fractions of 14C-labeled diazepam and tenoxicam in skimmed milk of various species (man, horse, goat, cow, sheep, dog, rabbit) with different milk compositions were determined. Furthermore, the protein binding of five 14C-labeled benzodiazepines differing in their lipophilicity (bromazepam, clonazepam, diazepam, flumazenil, and flunitrazepam) were measured in human milk and in artificially prepared solutions of individual milk proteins (lactoferrin, 2.4 g/liter; -lactalbumin, 2.1 g/liter; albumin, 0.4 g/liter; and casein—2.1, 3.4, and 13.3 g/liter). The extent of binding was determined by equilibrium dialysis of protein solution against 1/15 M phosphate buffer, made isocryoscopic with lactose. The results showed that the casein fraction is a major binding component in milk for all tested drugs. The extent of binding of diazepam and tenoxicam in the milk of various species was independent of the whey protein concentration. In human milk the fraction of bromazepam, clonazepam, diazepam, and flunitrazepam bound to casein was higher than that bound to any other of the milk proteins tested. Albumin contributed little to the overall binding of these benzodiazepines, and lactoferrin and -lactalbumin did not account for significant binding. The benzodiazepine antagonist flumazenil showed the lowest overall binding in milk and in casein solution. As the casein concentration is highest in colostral milk and drops during the course of lactation, it is expected that M/P ratios of drugs strongly bound to casein are higher during the first days postpartum than in later phases of lactation. 但是原稿 只有那种格式的了我是从 http://www.springerlink.com/content/x9586g687305v152/ 下来的 |
5楼2009-08-24 09:57:55
6楼2009-08-24 11:10:16
看着办给吧，我也不专业
★ ★ ★ ★ ★
liruiguang(金币+5,VIP+0):劳务费 要不你觉得不够我再加 谢谢MM了 8-24 15:56
liruiguang(金币+5,VIP+0):劳务费 要不你觉得不够我再加 谢谢MM了 8-24 15:56
| 用游离14C标记的地西泮和替诺昔康测定了不同组分不同物种的脱脂奶粉（包括牛，马，羊，狗，兔）。并在人奶和人造奶（乳铁蛋白2.4 g/l，乳清蛋白2.1 g/l，蛋白质0.4 g/liter;酪蛋白2.1, 3.4, and 13.3 g/liter)中测量了亲脂性不同的五个14C标记的巴比妥类物质（溴西泮，氯硝西泮,地西泮，氟马西尼，氟硝西泮）的蛋白质结合能力。结合的程度取决于乳糖与蛋白质和1/15M磷酸盐缓冲液的透析平衡。结果显示酪蛋白碎片是说有药物的主要结合成分。地西泮和替诺西康在不同奶中都不与酪蛋白结合。溴西泮、氯硝西泮,地西泮，氟硝西泮的人奶碎片中酪蛋白结合程度高于其他奶。从整体上来看，蛋白质与本巴比妥类药物结合程度小，乳铁蛋白、乳清蛋白没有显著结合能力。巴比妥类药物拮抗剂氟马西尼在奶和酪蛋白溶液中结合能力最差。由于初乳的蛋白浓度最大，随乳汁分泌过程逐渐减弱，估计药物与蛋白结合强度会随着产后乳汁期减弱。 |
7楼2009-08-24 15:52:52
liruiguang
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8楼2009-08-24 16:00:20
9楼2009-08-24 16:17:49
liruiguang
金虫 (正式写手)
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这个不能怪我 我一共就这些金币啊10楼2009-08-24 16:31:36
