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小木虫论坛-学术科研互动平台 » 生物医药区 » 药学 » 药理学 » 请教下关于青霉素在奶牛体内的代谢过程
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liruiguang

金虫 (正式写手)

[交流] 请教下关于青霉素在奶牛体内的代谢过程

RT从注射或口服到排出体外，特别是通过挤奶排出体外

请高手指点下  

最好有文献什么的
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1楼 2009-08-16 10:52:40
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lanwoco

铜虫 (小有名气)
★ ★
liruiguang(金币+1,VIP+0):高手 感谢参与讨论 8-20 17:46
karl2100(金币+1,VIP+0):谢谢应助！ 8-20 22:03
按照楼主的思路，可直接测定青霉素及其主要代谢产物与相关乳蛋白的结合率实验，可用超滤法或平衡膜透析法，获得的结合率值可为您提供参考。
以上是体外的方法，体内可选择与某种蛋白(比如牛血清蛋白或酪蛋白)具有更高结合率的药物，与青霉素合用，通过随机分组实验设计观察合用与否对青霉素乳汁排泄率的影响。
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5楼2009-08-20 15:42:18
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liruiguang

金虫 (正式写手)
怎么没有人  知道吗？
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2楼2009-08-20 08:28:57
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lanwoco

铜虫 (小有名气)
★ ★
小木虫(金币+0.5):给个红包，谢谢回帖交流
liruiguang(金币+1,VIP+0):非常感谢 8-20 15:11
文献很多的啦！

1.        Nagel, O.G., et al., Robust experimental design for optimizing the microbial inhibitor test for penicillin detection in milk. Letters in Applied Microbiology, 2009. 48(6): p. 744-749.
2.        Gao, X.J., et al., Detecting Penicillin in Milk with a Wireless Magnetoelastic Biosensor. Sensor Letters, 2009. 7(1): p. 6-10.
3.        Zhang, J.K., et al., Synthesis of Molecularly Imprinted Polymer for Sensitive Penicillin Determination in Milk. Analytical Letters, 2008. 41(18): p. 3411-3419.
4.        Thavarungkul, P., et al., Detecting penicillin G in milk with impedimetric label-free immunosensor. Biosensors & Bioelectronics, 2007. 23(5): p. 688-694.
5.        Sternesjo, A. and E. Gustavsson, Biosensor analysis of beta-lactams in milk using the carboxypeptidase activity of a bacterial penicillin binding protein. Journal of Aoac International, 2006. 89(3): p. 832-837.
6.        Hanway, W.H., et al., Inactivation of penicillin G in milk using hydrogen peroxide. Journal of Dairy Science, 2005. 88(2): p. 466-469.
7.        Popelka, P., et al., Comparison of sensitivity of various screening assays and liquid chromatography technique for penicillin residue detection in milk. Bulletin of the Veterinary Institute in Pulawy, 2004. 48(3): p. 273-276.
8.        Cacciatore, G., et al., Development of an optical biosensor assay for detection of beta-lactam antibiotics in milk using the penicillin-binding protein 2x. Analytica Chimica Acta, 2004. 520(1-2): p. 105-115.
9.        Berruga, M.I., et al., Performances of antibiotic screening tests in determining the persistence of penicillin residues in ewe's milk. Journal of Food Protection, 2003. 66(11): p. 2097-2102.
10.        Popelka, P., et al., Comparison of various methods for penicillin residue detection in cow milk after intramammary and parenteral treatment. Bulletin of the Veterinary Institute in Pulawy, 2003. 47(1): p. 203-209.
11.        Allara, M., et al., Penicillin G in pasteurized milk produced in Zulia State - Venezuela. Revista Cientifica-Facultad De Ciencias Veterinarias, 2002. 12(6): p. 683-687.
12.        Gustavsson, E., P. Bjurling, and A. Sternesjo, Biosensor analysis of penicillin G in milk based on the inhibition of carboxypeptidase activity. Analytica Chimica Acta, 2002. 468(1): p. 153-159.
13.        Anderson, K.L. and R.L. Lyman, Comparison of microbial receptor assay and liquid chromatography for determination of penicillin G and amoxicillin in milk powder. Journal of Aoac International, 2002. 85(3): p. 546-550.
14.        Huth, S.P., et al., Parallux (TM) beta-lactam: A capillary-based fluorescent immunoassay for the determination of penicillin-G, ampicillin, amoxicillin, cloxacillin, cephapirin, and ceftiofur in bovine milk. Journal of Aoac International, 2002. 85(2): p. 355-364.
15.        Musser, J.M.B., K.L. Anderson, and J.O. Boison, Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves. Journal of the American Veterinary Medical Association, 2001. 219(3): p. 346-350.
16.        Dubreuil, P., et al., Penicillin concentrations in serum, milk, and urine following intramuscular and subcutaneous administration of increasing doses of procaine penicillin G in lactating dairy cows. Canadian Journal of Veterinary Research-Revue Canadienne De Recherche Veterinaire, 2001. 65(3): p. 173-180.
17.        Musser, J.M.B. and K.L. Anderson, Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves. Journal of Veterinary Pharmacology and Therapeutics, 2001. 24(3): p. 161-169.
18.        Gaudin, V., J. Fontaine, and P. Maris, Screening of penicillin residues in milk by a surface plasmon resonance-based biosensor assay: comparison of chemical and enzymatic sample pre-treatment. Analytica Chimica Acta, 2001. 436(2): p. 191-198.
19.        Salter, R.S., et al., Charm safe-level beta-lactam test for amoxicillin, ampicillin, ceftiofur, cephapirin, and penicillin G in raw commingled milk. Journal of Aoac International, 2001. 84(1): p. 29-36.
20.        Musser, J.M.B., et al., Potential for milk containing penicillin G or amoxicillin to cause residues in calves. Journal of Dairy Science, 2001. 84(1): p. 126-133.
21.        Furusawa, N., Rapid liquid chromatographic determination of residual penicillin G in milk. Fresenius Journal of Analytical Chemistry, 2000. 368(6): p. 624-626.
22.        Liljebjelke, K.A., L.D. Warnick, and M.F. Witt, Antibiotic residues in milk following bulbar subconjunctival injection of procaine penicillin G in dairy cows. Journal of the American Veterinary Medical Association, 2000. 217(3): p. 369-371.
23.        Reyes, J.F.F., et al., Extraction and quantification of penicillin G on raw milk by high performance liquid chromatography (HPLC). Revista Cientifica-Facultad De Ciencias Veterinarias, 2000. 10(3): p. 212-221.
24.        Sarkar, P., A novel amperometric biosensor for detection of penicillin in milk. Journal of the Indian Chemical Society, 1999. 76(10): p. 495-497.
25.        Anderson, K.L., et al., Detection of milk antibiotic residues by use of screening tests and liquid chromatography after intramammary administration of amoxicillin or penicillin G in cows with clinical mastitis. American Journal of Veterinary Research, 1998. 59(9): p. 1096-1100.
26.        AliVehmas, T., et al., Binding of Staphylococcus aureus to milk fat globules increases resistance to penicillin-G. Journal of Dairy Research, 1997. 64(2): p. 253-260.
27.        Diserens, J.M., M. Richard, and A. Beck, Recovery of penicillin and sulfamethazine from contaminated milk after spray drying. Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk, 1995: p. 149-150
343.
28.        Lohuis, J.A.C.M., et al., Pharmacokinetics and milk: Residues of penicillin, nafcillin and dihydrostreptomycin in dairy sheep treated with nafpenzal(R) DC at drying-off. Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk, 1995: p. 64-68
343.
29.        Lehmann, F.L., 72 h milk withhold time: Is it sufficient for non-penicillin antibiotics? Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk, 1995: p. 69-72
343.
30.        Lohuis, J.A.C.M., et al., Milk residues of penicillin, nafcillin and dihydrostreptomycin in dairy goats postpartum treated with Nafpenzal N8(R) at drying-off. Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk, 1995: p. 75-76
343.
31.        Bygrave, J., M. Rose, and J. Tarbin, A comparison of screening and quantitative test methods for the determination of penicillin in milk. Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk, 1995: p. 266-268
343.
32.        Usleber, E., et al., Enzyme-Immunoassay for the Detection of Isoxazolyl Penicillin Antibiotics in Milk. Analyst, 1994. 119(12): p. 2765-2768.
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3楼2009-08-20 14:28:30
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liruiguang

金虫 (正式写手)
非常感谢 LS
但是这些都是青霉素检测类的文献

我主要研究的是 青霉素及其降解产物在牛奶中与乳蛋白结合形成复合物的研究
目前对于青霉素与具体哪个乳蛋白结合 还不是很清楚  想看看这方面的文献

现在知道牛血清蛋白 和酪蛋白很有可能
所以想通过青霉素代谢，药物动力学这方面下手
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4楼2009-08-20 15:14:29
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