| 查看: 313 | 回复: 0 | |||
[交流]
3-13岁变应性鼻炎伴哮喘儿童舌下含服粉尘螨滴剂的疗效和安全性
|
|
Background: Sublingual immunotherapy (SLIT) is recommended for allergic diseases. However, clinical studies containing evidence-based data of this treatment in young children, which is rarely reported in the literature, are needed. This study was designed to assess the efficacy and safety of SLIT in children, including very young children. Methods: Two hundred sixty-four children aged 3–13 years old (133 children, 3–5 years old) with Dermatophagoides farinae–induced allergic rhinitis with or without asthma treated by standard pharmacotherapy had randomly received either SLIT (SLIT group) or no SLIT (control group) for 12 months. Symptoms, medications, visual analog scale (VAS) and presence of adverse events (AEs) were ssessed at monthly visits. Skin-prick test and Dermatophagoides farinae-specific IgE and IgG4 were measured before and after treatment. Results: Both treatments were effective in the global clinical scores during the first seven visits when compared with baseline (all, p ＜0.01), and SLIT showed lower symptoms scores and VAS scores throughout this period (all, p ＜0.01). These improvements continued until the later visits only in the SLIT group. Also, the asthma medication consumption was decreased by SLIT treatment only at the end of study (p＜ 0.01). The specific IgG4 was significantly increased after SLIT treatment when compared with the control group, but no significant change of specific IgE was observed in either groups. In the SLIT group, there was no significant difference between children less than or more than 5 years old in terms of clinical efficacy, onset of action, immunologic parameters, and safety. No severe systemic AEs were reported. Conclusion: SLIT is effective and well-tolerated in children with allergic rhinitis 3–13 years old. |
回复此楼» 猜你喜欢
请问有做大鼠M1型小胶质细胞表面标志物CD86的免疫荧光冰冻切片染色成功的吗？
已经有0人回复
-
耳刺激疗法干预MDD、MCI临床实践指南”临床问题调研
已经有0人回复
-
内分泌系统/代谢和营养支持论文润色/翻译怎么收费?
已经有291人回复
-
注射用卡非佐米国内上市说明书
已经有1人回复
-
305医学求调剂
已经有0人回复
-
求调剂针推学硕
已经有10人回复
-
中医335调剂
已经有0人回复
-
北中医博导推荐
已经有17人回复
-
2025版药典1-4部 电子版另附2025药典和2020药典对比表
已经有9人回复
-
机制假说图
已经有3人回复