| 查看: 147 | 回复: 2 | |||
| 当前主题已经存档。 | |||
zjandzq金虫 (正式写手)
|
[交流]
翻译一段药理（请专业人士进），谢谢！！
|
||
|
The possibility that the drug may affect asthmatic inflammation, through inhibition of the relevant inflammatory cytokines, has not been explored. The purpose of this study was, firstly, to investigate the ability of andrographolide to inhibit the release of inflammatory cytokines in vitro in a model of non-specificinflammation and subsequently to determine whether such effect can also be exerted in vivo in allergic lung inflammation. LPS-induced TNF-α and GM-CSF release from mouse peritoneal macrophages was inhibited by andrographolide in a concentration-dependent manner. The concentration of the drug producing 50% inhibition was 0.6 μM for TNF-α and 3.3 μM for GM-CSF. The maximal inhibition achieved (at 50 μM) was 77% and 94%, respectively, for the two cytokines. The drug was as efficacious as dexamethasone, but about 8–12 times less potent. The drug also suppressed LPS-induced expression of mRNA for the two cytokines, suggesting that this effect may contribute to the mechanism underlying its anti-inflammatory effects. In the in vivo study, intra-peritoneal treatment of ovalbumin-immunized and nasally-challenged mice with andrographolide significantly inhibited the elevation of bronchoalveolar fluid (BAF) levels of TNF-α and GM- CSF in a dose-dependent manner, with 30 mg/kg producing an inhibition of 92% and 65% of the cytokines, respectively) and almost completely abolishing the accumulation of lymphocytes and eosinophils. |
回复此楼» 猜你喜欢
高分子化学与物理调剂
已经有7人回复
-
085600材料工程一志愿中科大总分312求调剂
已经有10人回复
-
材料类求调剂
已经有5人回复
-
298求调剂
已经有11人回复
-
284求调剂
已经有3人回复
-
面上模板改不了页边距吧？
已经有5人回复
-
276求调剂
已经有4人回复
-
博士推荐
已经有6人回复
-
0856材料求调剂
已经有11人回复
-
311求调剂
已经有7人回复
monitor2885
至尊木虫 (职业作家)
队长
- 翻译EPI: 15
- 应助: 6 (幼儿园)
- 贵宾: 0.339
- 金币: 39310.5
- 散金: 147
- 红花: 22
- 帖子: 4976
- 在线: 2169.7小时
- 虫号: 701577
- 注册: 2009-02-15
- 性别: GG
- 专业: 生态系统生态学
2楼2009-06-13 14:23:43
zjandzq
金虫 (正式写手)
- 应助: 4 (幼儿园)
- 金币: 1123
- 散金: 150
- 帖子: 530
- 在线: 228.3小时
- 虫号: 632649
- 注册: 2008-10-21
- 专业: 药物代谢与药物动力学
3楼2009-06-13 15:34:32
