| 查看: 148 | 回复: 2 | |||
| 当前主题已经存档。 | |||
zjandzq金虫 (正式写手)
|
[交流]
翻译一段药理（请专业人士进），谢谢！！
|
||
|
The possibility that the drug may affect asthmatic inflammation, through inhibition of the relevant inflammatory cytokines, has not been explored. The purpose of this study was, firstly, to investigate the ability of andrographolide to inhibit the release of inflammatory cytokines in vitro in a model of non-specificinflammation and subsequently to determine whether such effect can also be exerted in vivo in allergic lung inflammation. LPS-induced TNF-α and GM-CSF release from mouse peritoneal macrophages was inhibited by andrographolide in a concentration-dependent manner. The concentration of the drug producing 50% inhibition was 0.6 μM for TNF-α and 3.3 μM for GM-CSF. The maximal inhibition achieved (at 50 μM) was 77% and 94%, respectively, for the two cytokines. The drug was as efficacious as dexamethasone, but about 8–12 times less potent. The drug also suppressed LPS-induced expression of mRNA for the two cytokines, suggesting that this effect may contribute to the mechanism underlying its anti-inflammatory effects. In the in vivo study, intra-peritoneal treatment of ovalbumin-immunized and nasally-challenged mice with andrographolide significantly inhibited the elevation of bronchoalveolar fluid (BAF) levels of TNF-α and GM- CSF in a dose-dependent manner, with 30 mg/kg producing an inhibition of 92% and 65% of the cytokines, respectively) and almost completely abolishing the accumulation of lymphocytes and eosinophils. |
回复此楼» 猜你喜欢
调剂
已经有6人回复
-
一志愿 江南大学 085602 化工专硕 338分求调剂
已经有12人回复
-
材料专硕(0856) 339分求调剂
已经有8人回复
-
377求调剂
已经有5人回复
-
0703调剂，一志愿天津大学319分
已经有6人回复
-
一志愿南昌大学，085600，344分求调剂
已经有5人回复
-
308求调剂
已经有8人回复
-
找调剂
已经有9人回复
-
一志愿郑州大学085600求调剂
已经有12人回复
-
316求调剂
已经有3人回复
2楼2009-06-13 14:23:43
zjandzq
金虫 (正式写手)
- 应助: 4 (幼儿园)
- 金币: 1123
- 散金: 150
- 帖子: 530
- 在线: 228.3小时
- 虫号: 632649
- 注册: 2008-10-21
- 专业: 药物代谢与药物动力学
3楼2009-06-13 15:34:32
