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dabobo_lee金虫 (小有名气)
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法国波尔多大学诚招2020年CSC公派化学博士
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·¨?ú?¨???à?ó?§institute european chemistry and biology ?¨IECB) Guichard ????×é???????????? ??????Design and synthesis of foldamer-based enzyme mimetics ?ò?é?? In Nature, folding and function of biopolymers, such as proteins or nucleic acids, are two closely related notions that lead to an impressive variety of biological processes to occur. The design of bioinspired architectures to create innovative and functional nano(bio)systems in aqueous media has been a longstanding goal of the scientific community. Access to artificial enzymatic systems that would lead to efficient and new biocatalysts is of particular interest. Synthetic sequence-specific folded oligomers (also called ?°foldamers?±) possess interesting features to create self-assembled protein-like frameworks, with topologies similar to and beyond those of natural polypeptides. The ability of some foldamer backbones to form predictable and well-defined secondary structures, with helical folding properties being independent from the nature of the side-chain used (i.e. primary sequence), should facilitate morphological control at the nano-scale while displaying the desired functionalities. However, attempts to reproduce enzymatic activities using foldamer chemistry have remained limited thus far. Our group has pioneered the development and the structural characterization of aliphatic oligoureas as a new class of peptidomimetic foldamers during the last decade. The remarkable compatibility of their backbones with alpha-peptides has been recently demonstrated, highlighting thus the potential of interfacing natural peptides and ureabased backbones to create chimeric structures. Thus this PhD project aims to engineer de novo enzyme-like architectures using supramolecular assemblies of water-soluble peptide-oligourea chimera. ?ò???????ó?? ???????ú?????????????á?????¨±??°?¨NMR ,MS ?????? ????peptide ????????·?×????§???é??·????¤×÷???????????? ???è??·¨?????¨?? ???é???é???? CBMN-UMR 5248 Guichard ????×é???¨???à?ó?§??·¨?ú???§???¨CNRS??????×é????°ü?¨?¨???à?ó?§?°?¤??·¨?ú???§???????±?????????? ×é??????×??·?????????à???ú?????????ú???????ó??????·??§???????é?è±?????????°?????nice?? ?ê?é???????é???÷???? https://www.cbmn.u-bordeaux.fr/1 ... que.html#teamleader ?????¤?????§??·??? CV??cover letter ?? Morgane Pasco (m.pasco@iecb.u-bordeaux.fr, +33 5 4000 3015) ???????????????????ê?é?? FLYlbo |
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taebong
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dabobo_lee
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脠莽鹿没脦脼路篓脫脢录镁脫脨脦脢脤芒拢卢驴脡脪脭路垄碌陆脦脪脮芒脌茂掳茂脛茫脳陋路垄拢潞boli224@hotmail.com [ 路垄脳脭脢脰禄煤掳忙 https://muchong.com/3g ] |
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dabobo_lee
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7楼2019-12-04 03:24:58
dabobo_lee
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虏脦脮脮CSC脳卯碌脥脫茂脩脭脪陋脟贸隆拢 虏篓露没露脿麓贸脩搂脮芒卤脽脦脛录镁脡脧脨麓碌脛脢脟脮芒拢潞Proof of Language proficiency in English English Test: TOEFL PbT (min 550), or TOEFL (ibT min 79) or IELTS (min 6.5) or TOEIC (min 685) or proof of CEFR level B2 in English or French隆拢 陆篓脪茅脙禄脫脨鲁脡录篓脰庐脟掳脪虏驴脡脪脭脧脠脕陋脧碌拢卢脠禄潞贸录脤脨酶脳录卤赂驴录脢脭隆拢脕铆脥芒脥霉脛锚戮颅脩茅脫脨脳卯脰脮脦脼脫茂脩脭鲁脡录篓脪虏脥篓鹿媒碌脛脌媒脳脫 [ 路垄脳脭脢脰禄煤掳忙 https://muchong.com/3g ] |
8楼2019-12-04 03:32:37
dabobo_lee
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