| 查看: 2022 | 回复: 8 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
dabobo_lee金虫 (小有名气)
|
[交流]
法国波尔多大学诚招2020年CSC公派化学博士
|
||
|
·¨?ú?¨???à?ó?§institute european chemistry and biology ?¨IECB) Guichard ????×é???????????? ??????Design and synthesis of foldamer-based enzyme mimetics ?ò?é?? In Nature, folding and function of biopolymers, such as proteins or nucleic acids, are two closely related notions that lead to an impressive variety of biological processes to occur. The design of bioinspired architectures to create innovative and functional nano(bio)systems in aqueous media has been a longstanding goal of the scientific community. Access to artificial enzymatic systems that would lead to efficient and new biocatalysts is of particular interest. Synthetic sequence-specific folded oligomers (also called ?°foldamers?±) possess interesting features to create self-assembled protein-like frameworks, with topologies similar to and beyond those of natural polypeptides. The ability of some foldamer backbones to form predictable and well-defined secondary structures, with helical folding properties being independent from the nature of the side-chain used (i.e. primary sequence), should facilitate morphological control at the nano-scale while displaying the desired functionalities. However, attempts to reproduce enzymatic activities using foldamer chemistry have remained limited thus far. Our group has pioneered the development and the structural characterization of aliphatic oligoureas as a new class of peptidomimetic foldamers during the last decade. The remarkable compatibility of their backbones with alpha-peptides has been recently demonstrated, highlighting thus the potential of interfacing natural peptides and ureabased backbones to create chimeric structures. Thus this PhD project aims to engineer de novo enzyme-like architectures using supramolecular assemblies of water-soluble peptide-oligourea chimera. ?ò???????ó?? ???????ú?????????????á?????¨±??°?¨NMR ,MS ?????? ????peptide ????????·?×????§???é??·????¤×÷???????????? ???è??·¨?????¨?? ???é???é???? CBMN-UMR 5248 Guichard ????×é???¨???à?ó?§??·¨?ú???§???¨CNRS??????×é????°ü?¨?¨???à?ó?§?°?¤??·¨?ú???§???????±?????????? ×é??????×??·?????????à???ú?????????ú???????ó??????·??§???????é?è±?????????°?????nice?? ?ê?é???????é???÷???? https://www.cbmn.u-bordeaux.fr/1 ... que.html#teamleader ?????¤?????§??·??? CV??cover letter ?? Morgane Pasco (m.pasco@iecb.u-bordeaux.fr, +33 5 4000 3015) ???????????????????ê?é?? FLYlbo |
回复此楼» 猜你喜欢
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有4人回复
-
售SCI一区T0P文章，我:8O.55.1.O.54,科目全,可伽急
已经有4人回复
-
售SCI一区T0P文章，我:8.O.55.1.O54,科目全,可伽急
已经有4人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有6人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有6人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有4人回复
-
某top大学教授说“能够在市场中兑现的能力才是真能力”无比同意！
已经有13人回复
-
同一个分子，一条来自文献，一条来自AI——不告诉你答案，你会选哪条？
已经有7人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有4人回复
-
售SCI一区T0P文章，我:8.O.55.1.O54,科目全,可伽急
已经有4人回复
dabobo_lee
金虫 (小有名气)
- 应助: 1 (幼儿园)
- 金币: 753.2
- 散金: 57
- 红花: 2
- 帖子: 140
- 在线: 69.4小时
- 虫号: 2936304
- 注册: 2014-01-17
- 性别: GG
- 专业: 合成药物化学
9楼2019-12-05 13:48:24
| 本帖内容被屏蔽 |
3楼2019-12-03 23:12:35
| 本帖内容被屏蔽 |
4楼2019-12-03 23:21:28
| 本帖内容被屏蔽 |
5楼2019-12-03 23:27:50
