| 查看: 835 | 回复: 5 | |||
[交流]
单一和多重过敏呼吸道变应性疾病儿童屋尘螨舌下特异性免疫治疗的疗效和安全性 已有5人参与
|
|
Background: The efficacy of single-allergen-specific immunotherapy in polysensitized subjects is a matter of debate. This study aimed to investigate the efficacy of house dust mite (HDM) sublingual immunotherapy (SLIT) in monosensitized and polysensitized children. Methods: A total of 112 children, aged 4 to 13 years old, with HDM-induced respiratory allergic diseases were allocated to a monosensitized group (n = 56) or a polysensitized group (n = 56). Both groups were treated by standard pharmacotherapy and SLIT with Dermatophagoides farinae (American HDM) extracts for 52 weeks. Symptoms, medications, visual analogue scale (VAS), and presence of adverse events (AEs) were assessed once a month. Skinprick test (SPT) was done before and aer treatment. After treatment, subjects in the polysensitized group who completed the study were further analyzed as subgroup 1 (n=20) and subgroup 2 (n=15) according to the number of coexisting allergens. Results: Forty-one subjects in the monosensitized group and 35 subjects in the polysensitized group completed the study. The global clinical parameters had significantly improved after treatment, with no significant difference between the monosensitized and polysensitized group throughout this period (all p > 0.05). The comparison among the monosensitized group, subgroup 1, and subgroup 2 indicated that there was no significant difference in symptoms scores and VAS at each scheduled follow-up visit. Therewas also no significant difference in total medications score (TMS) in the monosensitized group, subgroup 1, and subgroup 2 after week 24 (all p > 0.05). No severe systemic AEs were reported. Conclusion: No significant difference was observed in the clinical effects of HDM SLIT between polysensitized and monosensitized children with respiratory allergic diseases. |
回复此楼» 猜你喜欢
临床医学 323求调剂！！
已经有0人回复
-
临床医学 323求调剂！！
已经有2人回复
-
医学免疫学论文润色/翻译怎么收费?
已经有138人回复
-
超声破碎
已经有0人回复
-
祈福国青能够得中
已经有31人回复
-
Dr.Petzold实验室现在正在招募心血管方向的PhD，欢迎大家报考
已经有11人回复
-
单晶CIF文件
已经有3人回复
-
求下载四个单晶CIF文件
已经有3人回复
-
fileCode应该没用
已经有11人回复
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
本帖内容被屏蔽 |
2楼2020-01-02 10:03:34
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
本帖内容被屏蔽 |
3楼2020-01-03 11:31:25
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
本帖内容被屏蔽 |
4楼2020-01-04 15:16:52
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
本帖内容被屏蔽 |
5楼2020-01-07 11:35:08
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
|
本帖内容被屏蔽 |
6楼2020-01-09 11:27:18
