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bio-polymer

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虫号: 112656

[资源] 【资源】Introduction to Macromolecular Crystallography

Introduction to Macromolecular Crystallography
By Alexander McPherson

Publisher: Wiley-Blackwell
Number Of Pages: 267
Publication Date: 2009-02-03
ISBN-10 / ASIN: 0470185902
ISBN-13 / EAN: 9780470185902

Product Description:

A comprehensive and approachable introduction to crystallography — now updated in a valuable new edition

The Second Edition of this well-received book continues to offer the most concise, authoritative, and easy-to-follow introduction to the field of crystallography. Dedicated to providing a complete, basic presentation of the subject that does not assume a background in physics or math, the book's content flows logically from basic principles to methods, such as those for solving phase problems, interpretation of Patterson maps and the difference Fourier method, the fundamental theory of diffraction and the properties of crystals, and applications in determining macromolecular structure.

This new edition includes a vast amount of carefully updated materials, as well as two completely new chapters on recording and compiling X-ray data and growing crystals of proteins and other macromolecules.

Richly illustrated throughout to clarify difficult concepts, this book takes a non-technical approach to crystallography that is ideal for professionals and graduate students in structural biology, biophysics, biochemistry, and molecular biology who are studying the subject for the first time.

Summary: Glaring Errors, how has no one noticed?
Rating: 2

I'm honestly a bit concerned that none of the professional reviews have brought this up; but there are some huge misrepresentations of wave/optical physics that occur in this book. Fortunately, these are all in the introductory chapters, which explain the physics of waves and diffraction for systems of points and planes, with the latter chapters (the ones that are arguably unique to this sort of book) generally error free, so that a person using this as an intro text will surely understand the methodology of x-ray crystallography and how to interpret a diffraction pattern. It's really unfortunate, however, how much of the beginning "background" is completely incorrect. Dr. McPherson writes that the electric and magnetic fields which constitute an electromagnetic wave are out of phase, such that the E field is maximum when the H is zero, and vice-versa. This is wrong: E and B are completely in phase and orthogonal, and while H's phase can meander depending on the medium, it is surely not universally 90 degrees, and certainly has nothing to do with conservation of energy, which is suggested in this book. Also, while a small error; he suggests that a dot product of two vectors is equal to the projection of one on the other, and vice-versa. He never mentions dividing by magnitude (or starting with unit vectors), and as such all of the arguments of his trig/exponential functions within Fourier transformations aren't dimensionless, which is mathematically incorrect and physically meaningless. While this may seem like a small error; as this book is meant for "biochemist, molecular biologists, and pharmacolgical scientists," any student who tries to walk page by page through the physics to understand crystallography will surely think the book is inconsistent, but will probably assume one's own incompetence and inability to grasp the concepts.
It seems as though this book must have been written by a biologist (not a physicist) who generally remembers his vector algebra and optics from undergrad but didn't bother to review or check any sources. I can't completely slam the book, as the last chapters are helpful on interpreting raw data, but as an intro text, how is this an excusable product?

Summary: Highly Recommended
Rating: 5

"...I highly recommend this book...in fact, I foresee it finding its way to the bookshelves of many faculty members, albeit with frequent removal for consultation as an educational tool!" (Clinical Chemistry, Vol. 49, No. 7, 2003)

Summary: Recommended Book
Rating: 5

"...this welcome addition to the introductory crystallographic literature should be well received...recommended..." (Choice, Vol. 40, No. 8, April 2003)

Summary: Excellent
Rating: 5

"...an excellent introductory text..." (Journal of Proteome Research, Vol. 2, No. 2, March/April 2003)

Summary: Masterful
Rating: 5

"...a masterful presentation of the theory and practice of crystallography as applied to large molecules. Any student or professional who wants to deepen his or her understanding of the field should work through this text. The clarity, completeness, and simplicity of [Dr. McPherson's] treatment are impressive." --Andrew J.Howard, Argonne National Laboratory, Argonne, Illinois, and Illinois Institute of Technology, Chicago, Illinois
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