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写毕业论文用到的一篇英文文献突然找不到了，只有正文部分内容，麻烦大神帮忙下载原文献，急急急！ 正文部分内容：Mesenchymal markers such as vimentin and fibronectin are upregulated and redistributed15. These changes cannot be secondary to the loss of E-cadherin, as transfection of E-cadherin is not enough to induce a reversion to an epithelial morphology59. This indicates that Snail must have additional targets that are independent of E-cadherin. Also relevant to EMT is the upregulation of RhoB, which is important for neural-crest development in chick embryos60, and is ectopically expressed in the chick neural tube after overexpression of Slug46.Regulation of this small GTPase, which is involved in actin rearrangements, links Snail and EMT with changes in cell shape and, hence, with the morphogenetic movements that occur during gastrulation and neural-crest delamination. Indeed, a Rho-mediated signalling cascade is crucial for the morphogenetic changes during Drosophila gastrulation, a pathway that involves the exchange factor RhoGEF2 in response to an extracellular signal called folded gastrulation (Fog)61.Considering that, genetically, Fog lies downstream of Snail62, it is tempting to speculate that Rho GTPases might also be indirect targets of Snail in the gastrulating fly. |
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