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【白色念珠菌摘要翻译】+【2009年5月19日中午12点】+【急】
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Candida albicans uses a network of multiple signaling pathways to control the yeast→hypha transition. These include a mitogen-activated protein kinase pathway through Cph1, the cAMP-dependent protein kinase pathway via Efg1, a pH-responsive pathway through Rim101, the Tup1-mediated repression through Rfg1 and Nrg1, and pathways represented by transcription factors Cph2, Tec1 and Czf1. These pathways control the transcription of a common set of hypha-specific genes, many of which encode known virulence factors. The link between the signaling pathways and hyphal elongation is currently unknown, but there is evidence to suggest that Cdc42 likely plays a key role in hyphal morphogenesis. Unlike pseudohyphal growth in Saccharomyces cerevisiae, hyphal elongation is regulated independently of the cell cycle. Cellular differences between pseudohyphae and hyphae are further revealed by septin localization. |
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kuailezi(金币+15,VIP+0):谢谢 5-19 17:54
kuailezi(金币+15,VIP+0):谢谢 5-19 17:54
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Candida albicans uses a network of multiple signaling pathways to control the yeast→hypha transition. These include a mitogen-activated protein kinase pathway through Cph1, the cAMP-dependent protein kinase pathway via Efg1, a pH-responsive pathway through Rim101, the Tup1-mediated repression through Rfg1 and Nrg1, and pathways represented by transcription factors Cph2, Tec1 and Czf1. These pathways control the transcription of a common set of hypha-specificgenes, many of which encode known virulence factors. The link between the signaling pathways and hyphal elongation is currently unknown, but there is evidence to suggest that Cdc42 likely plays a key role in hyphal morphogenesis. Unlike pseudohyphal growth in Saccharomyces cerevisiae, hyphal elongation is regulated independently of the cell cycle. Cellular differences between pseudohyphae and hyphae are further revealed by septin localization. 白色念珠菌利用多个信息转导途径来控制酵母→菌丝过渡。其中包括Cph1有丝分裂原激活蛋白激酶途径，Efg1 cAMP依赖蛋白激酶途径，Rim101 pH值反应途径，Nrg1和Rfg1 的Tup1介导阻遏机制，转录因子Cph2 ， Tec1和Czf1 代表了这些途径。这些途径控制着一套通用的菌丝特定基因的转录，其中许多编码已知的致病因子。信息转导途径和菌丝伸长之间的联系目前尚不清楚，但有证据表明， Cdc42在菌丝形态方面可能发挥关键作用。不像在酿酒酵母中假菌丝的生长，菌丝伸长在整个细胞周期中被控制。在假菌丝和菌丝之间的细胞差异通过胞裂蛋白定位进一步被揭示。 仅供参考  |
2楼2009-05-19 12:53:36
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