| 查看: 153 | 回复: 1 | |||
| 当前主题已经存档。 | |||
[交流]
【白色念珠菌摘要翻译】+【2009年5月19日中午12点】+【急】
|
|||
|
Candida albicans uses a network of multiple signaling pathways to control the yeast→hypha transition. These include a mitogen-activated protein kinase pathway through Cph1, the cAMP-dependent protein kinase pathway via Efg1, a pH-responsive pathway through Rim101, the Tup1-mediated repression through Rfg1 and Nrg1, and pathways represented by transcription factors Cph2, Tec1 and Czf1. These pathways control the transcription of a common set of hypha-specific genes, many of which encode known virulence factors. The link between the signaling pathways and hyphal elongation is currently unknown, but there is evidence to suggest that Cdc42 likely plays a key role in hyphal morphogenesis. Unlike pseudohyphal growth in Saccharomyces cerevisiae, hyphal elongation is regulated independently of the cell cycle. Cellular differences between pseudohyphae and hyphae are further revealed by septin localization. |
回复此楼» 猜你喜欢
退学或坚持读
已经有28人回复
-
有时候真觉得大城市人没有县城人甚至个体户幸福
已经有7人回复
-
天津大学招2026.09的博士生，欢迎大家推荐交流（博导是本人）
已经有3人回复
-
面上项目申报
已经有3人回复
-
酰胺脱乙酰基
已经有9人回复
-
CSC & MSCA 博洛尼亚大学能源材料课题组博士/博士后招生｜MSCA经费充足、排名优
已经有5人回复
-
博士延得我，科研能力直往上蹿
已经有7人回复
-
面上基金申报没有其他的参与者成吗
已经有5人回复
-
遇见不省心的家人很难过
已经有22人回复
myhaoqq
铁杆木虫 (著名写手)
小木虫警备司令员
- 翻译EPI: 1
- 应助: 17 (小学生)
- 金币: 6846.9
- 散金: 100
- 红花: 1
- 帖子: 1859
- 在线: 47.8小时
- 虫号: 334363
- 注册: 2007-03-30
- 性别: GG
- 专业: 能源化工
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
kuailezi(金币+15,VIP+0):谢谢 5-19 17:54
kuailezi(金币+15,VIP+0):谢谢 5-19 17:54
|
Candida albicans uses a network of multiple signaling pathways to control the yeast→hypha transition. These include a mitogen-activated protein kinase pathway through Cph1, the cAMP-dependent protein kinase pathway via Efg1, a pH-responsive pathway through Rim101, the Tup1-mediated repression through Rfg1 and Nrg1, and pathways represented by transcription factors Cph2, Tec1 and Czf1. These pathways control the transcription of a common set of hypha-specificgenes, many of which encode known virulence factors. The link between the signaling pathways and hyphal elongation is currently unknown, but there is evidence to suggest that Cdc42 likely plays a key role in hyphal morphogenesis. Unlike pseudohyphal growth in Saccharomyces cerevisiae, hyphal elongation is regulated independently of the cell cycle. Cellular differences between pseudohyphae and hyphae are further revealed by septin localization. 白色念珠菌利用多个信息转导途径来控制酵母→菌丝过渡。其中包括Cph1有丝分裂原激活蛋白激酶途径，Efg1 cAMP依赖蛋白激酶途径，Rim101 pH值反应途径，Nrg1和Rfg1 的Tup1介导阻遏机制，转录因子Cph2 ， Tec1和Czf1 代表了这些途径。这些途径控制着一套通用的菌丝特定基因的转录，其中许多编码已知的致病因子。信息转导途径和菌丝伸长之间的联系目前尚不清楚，但有证据表明， Cdc42在菌丝形态方面可能发挥关键作用。不像在酿酒酵母中假菌丝的生长，菌丝伸长在整个细胞周期中被控制。在假菌丝和菌丝之间的细胞差异通过胞裂蛋白定位进一步被揭示。 仅供参考  |
2楼2009-05-19 12:53:36