| 查看: 159 | 回复: 2 | |||
| 当前主题已经存档。 | |||
sxl0539木虫 (小有名气)
|
[交流]
急需文献一篇
|
||
| Akiyama H, Kudo S, Shimizu T. ..... Arzneim-Forsch 35: 1124-1132, 1985. 10. |
回复此楼» 猜你喜欢
8月时间戳变的，举个手。玩一下，释放压力
已经有11人回复
-
影响面上的因素
已经有6人回复
-
一个有机合成实验室都需要哪些设备？
已经有11人回复
-
求各位大神看下
已经有23人回复
-
面上再次挂了，太难了，躺也躺不了，倦也卷不过，小学校之殇！
已经有30人回复
-
2027年申博
已经有4人回复
-
好消息？这个有何含义？？？
已经有10人回复
-
咨询面上基金
已经有4人回复
-
【2027博士申请】纳米药物递送方向
已经有4人回复
-
UV压敏胶开发
已经有7人回复
hjw123
铜虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 1283.5
- 散金: 30
- 红花: 2
- 帖子: 501
- 在线: 126.6小时
- 虫号: 733117
- 注册: 2009-03-27
- 性别: GG
- 专业: 中药药效物质
2楼2009-05-13 21:23:55
hjw123
铜虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 1283.5
- 散金: 30
- 红花: 2
- 帖子: 501
- 在线: 126.6小时
- 虫号: 733117
- 注册: 2009-03-27
- 性别: GG
- 专业: 中药药效物质
★ ★ ★ ★ ★
sxl0539(金币+5,VIP+0): 5-14 00:59
sxl0539(金币+5,VIP+0): 5-14 00:59
|
文摘 The absorption, distribution and excretion of a new antithrombotic and vasodilating agent, cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)- qui nolinone, OPC-13013) was studied after the oral administration of cilostazol or 14C-cilostazol in rats, rabbits, dogs and man. After the oral administration of 14C-cilostazol at a dose of 10 mg/kg in male and female rats and rabbits, and at a dose of 3 mg/kg in dogs, the Tmax, Cmax and T1/2 of the radioactivity were 2 h, 710.5 ng eq X ml-1 and 2.5 h in male rats, 4 h, 11 002.8 ng eq X ml-1 and 3.7 h in female rats, 8 h, 358.1 ng eq X ml-1 and 6.9 h in rabbits, and 3 h, 559.4 ng eq X ml-1 and 1.6 h in dogs, respectively. After the oral administration of 14C-cilostazol at a dose of 10 mg/kg in rats, tissue concentrations of radioactivity in female rats were about 3 to 5 times as high as those in male rats. The blood and tissue concentrations of radioactivity in male and female rats showed a marked sex difference. However, the concentrations in the blood in both male and female rats declined rapidly. There was no evidence of the accumulation of radioactivity in the tissues due to repeated oral administrations of 14C-cilostazol at a dose of 3 mg/kg once a day for 21 days in male rats.(ABSTRACT TRUNCATED AT 250 WORDS) |
3楼2009-05-13 21:25:37