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中药及复方含有多种复杂成分,确定效应物质基础是进行PK/PD研究的一大难题。 目前,相关研究的发展有两种趋势。一种趋势仍以寻找中药及复方中的活性物质为研究重点。与以往研究的不同之处在于,该类研究充分考虑了中药“整体观”的特点和中药有效成分在体内的变化过程,综合运用多学科知识和现代先进的分离分析手段,构建中药及其复方吸收、分布、与靶细胞结合的体内外技术平台,通过寻找中药发挥作用的体内效应成分(群) ,来追溯其在中药直接提取物中的物质形式。另一种趋势伴随系统生物学和代谢组学的发展而产生。相关研究人员认为,不仅中药的原型成分和代谢产物与中药的治疗效应有关,中药与机体作用形成的新成分也在治疗中发挥作用,由这三者组成的代谢物组才是中药发挥治疗作用的物质基础。 |
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qingfeng877680(金币+6,VIP+0):谢谢您的翻译！友情提醒，兄弟可以升级了，呵呵！ 7-21 14:07
qingfeng877680(金币+6,VIP+0):谢谢您的翻译！友情提醒，兄弟可以升级了，呵呵！ 7-21 14:07
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Chinese medicine and a variety of complex components containing compound to determine the effect of the material is the basis of PK / PD study of a major problem. At present, the development of related research, there are two trends. Still looking for a trend of Chinese medicine and the compound of a focus on active substances. With previous studies is the difference between this area of research takes full account of traditional Chinese medicine, "the whole concept of" the characteristics and traditional Chinese medicine active ingredients of the change process in the body, the integrated use of multi-disciplinary knowledge and modern means of segregation analysis, building and its compound Chinese medicine absorption, distribution, and target cells in vivo and in vitro combination of technology platform, by seeking to play the role of Chinese medicine in vivo effects of components (groups), to trace its direct extract of Chinese medicine in the form of the material. Accompanied by another trend in systems biology and metabolomics have the development. Researchers believe that the medicine is not only a prototype and a product of the composition and metabolic effects of Chinese medicine treatment, the role of Chinese medicine and the body to form a new composition also play a role in treatment, by the composition of these three metabolites play group is the Chinese medicine treatment the material basis for the role. 专业术语不太懂，翻译的凡知道好不好 |
2楼2009-05-05 08:16:56
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COMPOSITION COMPRISING A COPOLYMER BASED ON ACRYLONITRILE AND A VINYL AROMATIC MONOMER, A COPOLYMER COMPRISING AT LEAST THREE BLOCKS AND A PARTICULATE COPOLYMER OF THE CORE-SHELL TYPE 这个标题里面有 THREE BLOCKS，在网上查找了一下，这个BLOCKS的意思还是不懂。 这句话能否这样翻译：一种基于丙烯腈和乙烯基单体芳烃成分组成的共聚物，其构成包括至少（三块？？）和一个核壳颗粒型的颗粒共聚物。 |
3楼2009-05-07 01:21:46
