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电子书分享《Crystallography Made Crystal Clear》
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Crystallography Made Crystal Clear by: Gale Rhodes Publisher: Academic Press Number Of Pages: 269 Publication Date: 2000-01-15 Sales Rank: 487565 ISBN / ASIN: 0125870728 EAN: 9780125870726 Binding: Paperback Manufacturer: Academic Press Studio: Academic Press Average Rating: 4.6 Total Reviews: 8  ——————————————————————————– Book Description: ) Macromolecules are the proteins and nucleic acids upon which life depends. Understanding the action of biological macromolecules (giant molecules) requires detailed knowledge of their structures. Most of the more than ten thousand known structures of protein and nucleic acids were obtained by x-ray crystallography, the standard mechanism for determining protein structure. Essentially, proteins are frozen into rigid crystals, which can be stacked up in a repeating pattern–like supermarket displays. The structure of each individual crystal can be determined by the way x-rays are bent when they pass through the composite crystal. Protein structure is essential when investigating protein interactions and planning drug development. Crystallography Made Crystal Clear, Second Edition explains how scientists discover the structures of the macromolecules. Scientists do not see these molecules directly. Instead, they build models as a means of interpreting data from x-ray diffraction by crystals, or by irradiation by other forms of energy. Users of these models need to know how they are obtained in order to know what they are seeing when they study a model of a macromolecule. They also need to know how to judge whether conclusions they draw from the molecular models are really supported by the models. This book uses visual and geometric models to help readers understand the mathematics that forms the basis of x-ray crystallography. The field of protein crystallography is growing every day and has been instrumental in discovering the molecular principles of biology and in discovering new drugs, such as the recent protease inhibitors for AIDS. The field includes the largest percentage of Nobel prizes than any other scientific discipline. Every major university and drug company has a protein crystallography laboratory and this book is an invaluable aid to those wishing to practice protein crystallography or just learn more about how it is actually done. Key Features * Provides clear, understandable descriptions of principles of X-ray crystallography * Leads reader through unintimidating and thorough explanations of the underlying mathematics * Provides abundant illustrations, including diagrams, charts, photographs, and color stereo * images * Explains how to read crystallography papers in research journals * Includes brief descriptions of other diffraction methods (neutron, electron, Laue) and the kinds * of structural information they can provide * Introduces other methods of macromolecular structure determination (NMR spectroscopy and * homology modeling), and provides guidance in judging the quality of these models ——————————————————————————– Date: 2007-01-17 Rating: 5 Review: Crystal Clear The delivery was prompt and in the item was in an excellent condition Date: 2006-12-07 Rating: 3 Review: Clear, but lack depth and practice problem Crystallography Made Crystal Clear does clearly explain the principles of X-ray Crystallography. I used this book for a graduate class in introductory x-ray crystallography when I deemed that the assigned book for the class, Principles of Protein X-Ray Crystallography, unhelpful. Crystallography Made Crystal Clear presents the theory behind crystallography in the most straightforward way possible. Whenever possible, concepts are explained in words and by examples instead of with equations. This elimates derivations that are not necessary to understand key concepts. Although explanations in the book are clear, they are often too brief. The book also does not have any practice problems, which is a major drawback. If you are taking a crystallography class, I would take a look at this book but focus more heavily on the lecture notes and problems from class. Honestly, I haven’t found a really good crystallography book, but this one at least is not too confusing. Date: 2005-01-30 Rating: 5 Review: Clear as a crystal!!!! This book is a good one. Explains every aspect I always want to know about crystallography. In my first class of biochemistry I discover that I really like the macromolecular models, but my biochemistry book doesn’t content much information about this subjet. When I discover this book I bought it, and read it, and I must to say that this book explain every aspect of the process of create a molecular model. After read this book I thinking about to become a crystallographer. Date: 2004-06-15 Rating: 5 Review: The best introduction to the subject This is the best introduction to crystallography I have ever come across. Which is quite an achievement, because its a difficult subject to understand. In crystallography, its very rare to find a book which does not deal with either a totally descriptive approach or a totally mathematical approach. Rhodes’ book bridges the gap between the two and gives the reader the right dose of jargon and explanation. He illustrates every point with plenty of figures as well as real life computer models of proteins. Before I came across this book, I was struggling and failing to understand Isomorphous Replacement, MAD, Solvent Flattening, Maps and Models, as well as the iterative refining of models. I think no other book comes even close to this book in explaining all these concepts in simple format. This, I think is as clear as it can get without becoming oversimplified. A must have for all researchers and students whose work is even remotely connected to crystallography. Date: 2003-06-04 Rating: 5 Review: "The" clearest one out there…. When it comes to this field of research, you get two types of references: (1) the 2-5 page quick intro that leaves you with the most basic overview of crystallography and (2) the ‘hard core’ books that go into such detail as to leave you breathless. This book is, in my opinion, the best transition book. For non-crystallographers, this book will teach enough about crystallography to allow you to read crystal structure articles and understand what is meant by all of the used statistics and such. For apprentice crystallographers, this is a wonderful intro into the field. Master the book, then move on to harder books to master it. Highly recommended. I still go back to it, when I teach people, to help me explain in the way that Gale Rhodes does! Free download Links http://ifile.it/ru2xal4/56597___cmcc-2nd.rar http://rapidshare.com/files/25534814/CMCC-2nd.rar.html |
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