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The purpose of this study was to develop a method for the stereoselective analysis of thioridazine-2-sulfoxide (THD-2-SO) and thioridazine-5-sulfoxide (THD-5-SO) in culture medium and to study the biotransformation of rac-thioridazine (THD) by some endophytic fungi. The simultaneous resolution of THD-2-SO and THD-5-SO diastereoisomers was performed on a CHIRALPAK® AS column using a mobile phase of hexane:ethanol:methanol (92:6:2, v/v/v) + 0.5%diethylamine; UV detection was carried out at 262 nm. Diethyl ether was used as extractor solvent.The validated method was used to evaluate the biotransformation of THD by 12 endophytic fungi isolated from Tithonia diversifolia, Viguiera arenaria and Viguiera robusta.Among the 12 fungi evaluated, 4 of themdeserve prominence for presenting an evidenced stereoselective biotransformation potential: Phomopsis sp. (TD2) presented greatermono-2-sulfoxidation to the form(S)-(SE) (12.1%);Glomerella cingulata (VA1) presented greater mono-5-sulfoxidation to the forms (S)-(SE) + (R)-(FE) (10.5%); Diaporthe phaseolorum (VR4) presented greater mono-2-sulfoxidation to the forms (S)-(SE) and (R)-(FE) (84.4% and 82.5%, respectively) and Aspergillus fumigatus (VR12) presented greater mono-2-sulfoxidation to the forms (S)-(SE) and (R)-(SE) (31.5% and 34.4%, respectively). 真菌名词可以不翻译。。。。 |
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liubencai
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fjtcm8772(金币+5,VIP+0): 5-1 18:54
fjtcm8772(金币+5,VIP+0): 5-2 19:12
fjtcm8772(金币+5,VIP+0): 5-1 18:54
fjtcm8772(金币+5,VIP+0): 5-2 19:12
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Phomopsis sp. (TD2) presented greater mono-2-sulfoxidation to the form (S)-(SE) (12.1%); 较好的单-2-磺化氧化作用使得拟茎点霉属(TD2)得到(S)-(SE)形式(12.1%)； Glomerella cingulata presented greater mono-5-sulfoxidation to the forms (S)-(SE) + (R)-(FE) (10.5%); 较好的单-5-磺化氧化作用使得围小丛壳(VA1)得到(S)-(SE) + (R)-(FE)形式(10.5%); Diaporthe phaseolorum (VR4) presented greater mono-2-sulfoxidation to the forms (S)-(SE) and (R)-(FE) (84.4% and 82.5%, respectively) and Aspergillus fumigatus (VR12) presented greater mono-2-sulfoxidation to the forms (S)-(SE) and (R)-(SE) (31.5% and 34.4%, respectively). 较好的间单-2-磺化氧化作用使得座壳属phaseolorum (VR4)得到(S)-(SE)和(R)-(FE)形式(分别是84.4%和82.5%)以及较好的单-2-磺化氧化作用使得烟曲霉(VR12)得到(S)-(SE)和(R)-(SE)形式(分别是31.5%和34.4%)。 |
3楼2009-05-01 08:49:28
liubencai
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fjtcm8772(金币+5,VIP+0): 5-1 18:54
fjtcm8772(金币+5,VIP+0): 5-1 18:54
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The purpose of this study was to develop a method for the stereoselective analysis of thioridazine-2-sulfoxide (THD-2-SO) and thioridazine-5-sulfoxide (THD-5-SO) in culture medium and to study the biotransformation of rac-thioridazine (THD) by some endophytic fungi. 本研究的目的是研究在培养介质中甲硫哒嗪-2-亚砜 (THD-2-SO)和甲硫哒嗪-5-亚砜 (THD-5-SO)的立体选择性分析，以及通过某些内生真菌研究外消旋-甲硫哒嗪(THD)的生物转化。 (甲硫哒嗪又称硫利达嗪) The simultaneous resolution of THD-2-SO and THD-5-SO diastereoisomers was performed on a CHIRALPAK® 在CHIRALPAK®手性柱上将THD-2-SO和THD-5-SO的非对映异构体同时分辨开； AS column using a mobile phase of hexane:ethanol:methanol (92:6:2, v/v/v) +diethylamine; 柱子用己烷:乙醇:甲醇(92:6:2, v/v/v)+ 0.5%二乙胺作为流动相； UV detection was carried out at 262 nm. 在262 nm进行紫外监测。 Diethyl ether was used as extractor solvent. 乙醚用作萃取溶剂(淋洗剂)。 The validated method was used to evaluate the biotransformation of THD by 12 endophytic fungi isolated from Tithonia diversifolia, Viguiera arenaria and Viguiera robusta. 该有效的方法用于评价THD的生物转化是通过从肿柄菊、Viguiera arenaria和Viguiera robusta分离出来的12种内生真菌进行的。 Among the 12 fungi evaluated, 4 of them deserve prominence for presenting an evidenced stereoselective biotransformation potential: 被评价的12种真菌中，其中4种得到了呈现出有证据的立体选择生物转化的潜质。 [ Last edited by liubencai on 2009-5-1 at 07:51 ] |
2楼2009-04-30 23:47:53
zw0912
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4楼2009-05-01 22:25:01
