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Ankh吧唧新虫 (小有名气)
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[求助]
请问药物诱导的小鼠肝损伤模型用什么种类的鼠好一些 已有2人参与
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如题，科研萌新，希望前辈指点。 发自小木虫IOS客户端 |
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【答案】应助回帖
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A study was made in inbred mice of genetic determinants of toxic liver cell injury. Carbon tetrachloride was injected s.c. in sublethal doses to induce liver cell damage in 4 strains of mice, BALB/c, C3H, C57BL/6 and SJL/J. Mice of the SJL/J strain were the least susceptible and showed minor hepatocellular necrosis, which resolved by Day 7, and a slight histiocytic response. C3H and C57BL/6 showed lesions which were intermediate between the other 2 strains. The autoantibody response to LSP was weak, transient and detected only in C57BL/6 mice. Strain differences in mice in carbon tetrachloride-induced liver injury. Br J Exp Pathol. 1983 Oct; 64(5): 524–533. |
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