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以成分群或代谢物组为效应物质基础来进行PK/PD研究,有利于从整体上把握中药及复方的代谢特点和效应机制,但是,同时也带来一个问题。成分群和代谢物组的各组成成分在体内的吸收、分布、转化、排泄的过程都具有自身的特点,如何整合这些复杂数据得到药物的代谢动力学特征、并与效应指标形成关联,成为摆在研究人员面前的新难题。 近年来在PK/PD研究中得到应用的人工神经网络为解决以上问题提供了可能。这种计算体系不需要先假定一个特定的模型,而只需从提供给它们的数据中建立输入与输出的关系,极大地简化了传统药动学数据分析所需的建模工作,而且无论是在预示能力还是预示速度方面都有显著提高。Minor等的研究表明,用人工神经网络能够将给药情况与PD、给药情况与PK、PD与PK或其它与治疗相关的因素直接关联起来,获得它们之间的关系。人工神经网络因其出色的非线性拟合能力有望成为中药及复方PK/PD研究中一种有效的数据分析工具。 代谢组学研究常运用化学计量学理论和多元统计分析方法,对采集的海量多维原始信息进行压缩降维和归类分析,最终以较少的独立主成分综合体现原多维变量中蕴含的绝大部分整体信息(习惯上> 85% )。这种研究策略在最大化保留信息的前提下大大简化了数据分析的难度和工作量,值得中药PK/PD结合研究人员借鉴。 |
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zw0912
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zap65535(金币+0,VIP+0):机器翻译 12-22 02:03
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Group or a component group for the effect of metabolites to the material basis of PK / PD study will help to grasp the overall metabolism of the compound traditional Chinese medicine and the characteristics and effects of the mechanism, but also brought a problem. Metabolite composition of groups and group composition of the in vivo absorption, distribution, transformation, the process of excretion are the characteristics of their own, how to integrate these complex data pharmacokinetics of drugs and associated with the effect of indicators of the formation to become researchers on the new challenges before. In recent years in PK / PD studies the application of artificial neural network to solve the above problems as possible. This calculation presumes that the system does not require a specific model, but only from their data available to establish the relationship between input and output, greatly simplifying the traditional pharmacokinetic analysis of data required for modeling work, and whether it is foreshadowed in the rate indicates the ability or have markedly improved. Minor and other studies have shown that artificial neural networks can be administered with the PD, with the administration of PK, PD and PK, or other relevant factors and treatment associated with direct access to the relationships between them. Artificial neural network because of its excellent ability to non-linear fitting of compound Chinese medicine and is expected to become PK / PD study of an effective data analysis tools. Metabolomics Research Chemometrics regular use of the theory and multivariate statistical analysis methods, the mass of collected information for the original multi-dimensional compression and classification analysis of dimensionality reduction, which will eventually lower the principal component of an independent integrated multi-dimensional manifestation of the original variables must contain the Most of the overall information (the habit of> 85%). This research strategy to maximize the retention of information in the premise of data greatly simplifies the analysis of the difficulty and workload, it is medicine PK / PD combination of researchers from |
2楼2009-04-21 19:32:48
仅供参考
zap65535(金币+0,VIP+0):机器翻译 12-22 02:03
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Study on group or a component group for the effect of metabolites to the material basis of PK / PD will help to grasp the overall metabolism of the compound traditional Chinese medicine and the characteristics and effects of the mechanism, but also brought a problem.Metabolite composition of groups and group composition of the in vivo absorption, distribution, transformation, the process of excretion are the characteristics of their own, how to integrate these complex data pharmacokinetics of drugs and associated with the effect of indicators of the formation to become researchers on the new challenges before. In recent years in PK / PD studies the application of artificial neural network to solve the above problems as possible.This calculation presumes that the system does not require a specific model, but only from their data available to establish the relationship between input and output, greatly simplifying the traditional pharmacokinetic analysis of data required for modeling work, and whether it is foreshadowed in the rate indicates the ability or have markedly improved. Minor and other studies have shown that artificial neural networks can be administered with the PD, with the administration of PK, PD and PK, or other relevant factors and treatment associated with direct access to the relationships between them. Artificial neural network because of its excellent ability to non-linear fitting of compound Chinese medicine and is expected to become PK / PD study of an effective data analysis tools. Metabolomics Research Chemometrics regular use of the theory and multivariate statistical analysis methods, the mass of collected information for the original multi-dimensional compression and classification analysis of dimensionality reduction, which will eventually lower the principal component of an independent integrated multi-dimensional manifestation of the original variables must contain the Most of the overall information (the habit of> 85%).This research strategy to maximize the retention of information in the premise of data greatly simplifies the analysis of the difficulty and workload, it is medicine PK / PD combination of researchers from. |
3楼2009-04-22 10:24:15
4楼2009-04-22 16:53:04
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5楼2009-04-22 17:55:15
