| 查看: 55 | 回复: 1 | |||
| 当前主题已经存档。 | |||
[交流]
求助文章，深表谢意！
|
|||
| PDA J Pharm Sci Technol. 2005 Sep-Oct;59(5):332-7. |
回复此楼» 猜你喜欢
二次调剂求老师收留
已经有3人回复
-
349学科化学045106求调剂，化学类都可以
已经有5人回复
-
一志愿0807 数一英一 313 有没有二轮调剂
已经有6人回复
-
求调剂，262机械专硕
已经有5人回复
-
286求调剂
已经有15人回复
-
0860004 求调剂 309分
已经有3人回复
-
材料类284调剂
已经有20人回复
-
调剂
已经有11人回复
-
考研调剂-材料类-284
已经有13人回复
-
复试调剂，一志愿郑州大学材料与化工289分
已经有13人回复
★
jsys(金币+1,VIP+0):感谢参与！ 4-9 15:45
jsys(金币+1,VIP+0):感谢参与！ 4-9 15:45
|
1: PDA J Pharm Sci Technol. 2005 Sep-Oct;59(5):332-7.Links Simple HPLC determination of benzalkonium chloride in ophthalmic formulations containing antazoline and tetrahydrozoline.Rojsitthisak P, Wichitnithad W, Pipitharome O, Sanphanya K, Thanawattanawanich P. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. pornchai.r@chula.ac.th A simple and rapid analytical procedure for routine quantification of n-C12H25 and n-C14H29 benzalkonium chloride (C-12 and C-14 BKC) homologs in ophthalmic formulations containing antazoline HCl and tetrahydrozoline HCl by high-performance liquid chromatography was developed and validated. The ophthalmic solution samples can be directly analyzed by reversed-phase on HiQ-Sil C18 column (4.6 mm x 150 mm, i.d., 5-microm particle size) with acetonitrile-sodium acetate buffer (pH 5.0; 0.2 M) (70:30, v/v) as mobile phase. UV Detection was carried out at 262 nm. The method was linear over the selected concentration and ranged from 0.03 to 0.10 mg/ml (r2 = 0.9999) and from 0.01 to 0.05 mg/ml (r2 = 0.9979) for C-12 and C-14 BKC homologs, respectively. The mean percent recoveries were 100.2 and 102.6 and the percent CV values were 1.3 and 3.5 for C-12 and C-14 BKC homologs, respectively. The results demonstrated the good linearity, accuracy, and precision. The method was applied to determine two commercial ophthalmic formulations, and the percent label amounts of total BKC contents were found to be 99.7 and 103.2. |
2楼2009-04-09 15:43:41
