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xiandongzeng木虫 (正式写手)
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| 求助WOS入藏号,DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis, Oncotarget, 2017,8(64): 107612–107620. |
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baiyuefei
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风雪
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xiandongzeng: 金币+5, ★★★★★最佳答案, 3Ks 2018-09-18 09:12:29
心静_依然: LS-EPI+1, 感谢应助 2018-09-19 08:37:31
感谢参与，应助指数 +1
xiandongzeng: 金币+5, ★★★★★最佳答案, 3Ks 2018-09-18 09:12:29
心静_依然: LS-EPI+1, 感谢应助 2018-09-19 08:37:31
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DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis 作者:Li, JX (Li, Junxin)[ 1,2 ] ; Xie, N (Xie, Ni)[ 3 ] ; Yuan, JH (Yuan, Jianhui)[ 4 ] ; Liu, LY (Liu, Lvyan)[ 1 ] ; Zhou, QM (Zhou, Qiming)[ 5 ] ; Ren, XH (Ren, Xiaohu)[ 4 ] ; Chen, Q (Chen, Qian)[ 1,2 ] ; Zhang, GZ (Zhang, Guizhong)[ 1 ] ; Ruan, QG (Ruan, Qingguo)[ 1 ] ; Chen, YHH (Chen, Youhai H.)[ 6 ] ...更多内容 ONCOTARGET 卷: 8 期: 64 页: 107612-107620 DOI: 10.18632/oncotarget.22544 出版年  EC 8 2017文献类型:Article 查看期刊影响力 摘要 Decoy receptor 3 (DcR3) is abnormally up-regulated in many cancer cells. It may help cancer cells to escape from immune surveillance and establish metastatic lesions. However, whether DcR3 can be used as a biomarker for the diagnosis of cancer metastasis is unclear. In this study, sera from healthy controls and patients with different cancers were collected, and tested for their DcR3 levels by ELISA. Significantly elevated DcR3 levels were observed in the sera of patients with gastric cancer (2.04 +/- 1.01, P = 0.0061), lymphoma (1.62 +/- 0.75, P = 0.041), and breast cancer (1.53 +/- 0.51, P = 0.023). DcR3 was found to be a suitable biomarker for identifying gastric cancer patients. Importantly, DcR3 was positively associated with platelet distribution width (PDW) (P = 2.45 x 10(-6), R = 0.63) in metastatic cancers but negatively associated with hemoglobin (HGB) (P = 0.002, R = -0.59) and hematocrit (HCT) (P = 0.001, R = -0.62) in non-metastatic cancers. Combined with PDW, HGB and HCT, serum DcR3 could be used to predict the occurrence of cancer metastasis. These findings indicate that DcR3 could be used as a biomarker for the diagnosis of gastric cancer, and for cancer metastasis in combination with hematological traits. 关键词 作者关键词 cR3; PDW; HGB; HCT; metastasisKeyWords Plus ECOY RECEPTOR-3; E-CADHERIN; GASTRIC-CANCER; CELL-ADHESION; COLON-CANCER; EXPRESSION; PROGRESSION; CARCINOMA; APOPTOSIS; CATENIN作者信息 通讯作者地址: Wan, XC (通讯作者) 显示更多 Univ City Shenzhen, Shenzhen Lab Fully Human Antibody Engn, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol,Chinese Acad Sci, Shenzhen 518055, Peoples R China. 地址: 显示更多 [ 1 ] Univ City Shenzhen, Shenzhen Lab Fully Human Antibody Engn, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol,Chinese Acad Sci, Shenzhen 518055, Peoples R China 显示更多 [ 2 ] Univ Chinese Acad Sci, Beijing 100049, Peoples R China 显示更多 [ 3 ] Shenzhen Second Peoples Hosp, Inst Translat Med, Shenzhen 518035, Peoples R China [ 4 ] Shenzhen Ctr Dis Control & Prevent, Inst Toxicol, Shenzhen 518055, Peoples R China [ 5 ] Nanshan Hosp Shenzhen, Dept Oncol, Shenzhen 518055, Peoples R China 显示更多 [ 6 ] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA 电子邮件地址:xc.wan@siat.ac.cn 基金资助致谢 基金资助机构 授权号 Shenzhen Peacock Team Project 1110140040347265 Fourth Batch of Talents Project in Guangdong Province 2014-1 Nature Science Foundation of China 81373112 Shenzhen Special Funds of Industry in the Future 2015-971 Shenzhen Municipal Development and Reform Commission (NDRC) Engineering Laboratory Project 2014-1782 Project of Guangdong Natural Science Foundation 2016A030310033 Project of Shenzhen Basic Research Plan JCYJ20150402102135491 JCYJ201603 28161613864 Shenzhen Technology Innovation Progect JSGG20160229202150023 JSGG20140701164558078 JCYJ20150330102720122 Project of Shenzhen International Cooperation Foundation GJHZ201603 01163138685 GJHZ20130412153906740 Natural Science Foundation of Guangdong 2016A030313029 Natural Science Foundation of China 81501356 Project of Guangdong Scientific Plan Foundation 2013A022100037 2013B021800097 2014A020212038 查看基金资助信息 出版商 IMPACT JOURNALS LLC, 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA 类别 / 分类 研究方向:Oncology; Cell Biology Web of Science 类别:Oncology; Cell Biology 文献信息 语言:English 入藏号: WOS:000419564600024 PubMed ID: 29296192 ISSN: 1949-2553 其他信息 IDS 号: FS1UR Web of Science 核心合集中的 "引用的参考文献": 41 Web of Science 核心合集中的 "被引频次": 0 |
2楼2018-09-18 08:48:11
