| 查看: 446 | 回复: 1 | ||
| 本帖产生 1 个 ，点击这里进行查看 | ||
纵朝阳木虫 (正式写手)
|
[求助]
查询文章是否被EI收录 谢谢
|
|
|
题目：Synthetic Process of 4-Methoxy-3-( 3-morpholinopropoxy) benzonitrile 期刊：精细化工 （Fine chemicals） 作者：ZONG Chao-yang，LI Miao-miao，SUN Guo-xiang，SUN Ya-quan |
回复此楼» 猜你喜欢
依托企业入选了国家启明计划青年人才。有无高校可以引进的。
已经有5人回复
-
博士延得我，科研能力直往上蹿
已经有9人回复
-
遇见不省心的家人很难过
已经有23人回复
-
天津大学招2026.09的博士生，欢迎大家推荐交流（博导是本人）
已经有6人回复
-
AI 太可怕了，写基金时，提出想法，直接生成的文字比自己想得深远，还有科学性
已经有6人回复
-
有院领导为了换新车，用横向课题经费买了俩车
已经有9人回复
-
酰胺脱乙酰基
已经有13人回复
-
同年申请2项不同项目，第1个项目里不写第2个项目的信息，可以吗
已经有4人回复
-
有时候真觉得大城市人没有县城人甚至个体户幸福
已经有10人回复
baiyuefei
版主 (文学泰斗)
风雪
- 应助: 4642 (副教授)
- 贵宾: 46.969
- 金币: 658186
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69392
- 在线: 13303.4小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
- 管辖: 有机交流
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
纵朝阳: 金币+50, ★★★★★最佳答案 2018-09-10 16:56:27
心静_依然: LS-EPI+1, 感谢应助 2018-09-11 13:33:56
感谢参与，应助指数 +1
纵朝阳: 金币+50, ★★★★★最佳答案 2018-09-10 16:56:27
心静_依然: LS-EPI+1, 感谢应助 2018-09-11 13:33:56
|
Synthetic Process of 4-Methoxy-3-(3-morpholinopropoxy)benzonitrile Accession number: 20182905573947 Authors: Zong, Chao-Yang 1 ; Li, Miao-Miao 2 ; Sun, Guo-Xiang 2 ; Sun, Ya-Quan 3 , 4 Author affiliations : 1 College of Chemical Engineering, Nanjing Tech University, Nanjing; Jiangsu; 210000, China 2 School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng; Jiangsu; 224051, China 3 School of Pharmacy, Yancheng Teachers University, Yancheng; Jiangsu; 224051, China 4 Jiangsu Marine Industry Research Institute, Dafeng; Jiangsu; 224100, China Corresponding author: Sun, Ya-Quan (sunyaquan@hotmail.com) Source title: Jingxi Huagong/Fine Chemicals Abbreviated source title: Jingxi Huagong Volume: 35 Issue: 3 Issue date: March 15, 2018 Publication Year: 2018 Pages: 525-528 Language: Chinese ISSN: 10035214 CODEN: JIHUFJ Document type: Journal article (JA) Publisher: Fine Chemicals Abstract: 3-Hydroxy-4-methoxybenzonitrile was synthesized from isovanillin and hydroxylamine hydrochloride by dehydration. And then 4-methoxy-3-(3-morpholinopropoxy)benzonitrile was synthesized by alkylation of 3-hydroxy-4-methoxybenzonitrile with 4-(3-chloropropyl)morpholine. The structures of product were characterized by IR and nuclear magnetic resonance (NMR). The optimum reaction conditions for the synthesis of 3-hydroxy-4-methoxybenzonitrile were as follows: n(isovanillin):n(hydroxylamine hydrochloride)=1:2, acetonitrile as solvent, reaction temperature 72℃, reaction time 6 hours. Under these conditions, the yield of 3-hydroxy-4-methoxybenzonitrile reached 96%. The yield of 4-methoxy-3-(3-morpholinopropoxy)benzonitrile reached 96% under the optimum reaction conditions of n(3-hydroxy-4-methoxybenzonitrile):n[N-(3-chloropropyl)morpholine]=1.0:1.1, acetonitrile as solvent, reaction time 6 hours at reflux temperature. After two steps of optimization, the target compound with high yield was obtained. The post-treatment is simple and more suitable for industrial production. © 2018, Editorial Office of FINE CHEMICALS. All right reserved. Number of references: 17 Main heading: Nuclear magnetic resonance Controlled terms: Acetonitrile - Amines - Aromatic compounds - Organic solvents Uncontrolled terms: Benzonitriles - Drug materials - Gefitinib - Hydroxylamine hydrochloride - Industrial production - Isovanillin - Nuclear Magnetic Resonance (NMR) - Optimum reaction conditions Classification code: 804.1Organic Compounds Numerical data indexing: Percentage 9.60e+01%, Time 2.16e+04s DOI: 10.13550/j.jxhg.2018.03.025 Database: Compendex Compilation and indexing terms, © 2018 Elsevier Inc. |
2楼2018-09-10 15:15:39