| 查看: 1394 | 回复: 2 | |||
[求助]
医学文献中的专业名词 已有2人参与
|
|
请问 off-target 准确翻译为啥？我说是脱靶，小老板说不对应该是远隔。。。所以究竟是啥意思？ 发自小木虫IOS客户端 |
回复此楼» 猜你喜欢
售SCI一区T0P文章，我:8O.55.1.O.5.4,科目齐全,可+急
已经有5人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有3人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有5人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有5人回复
-
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有3人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有5人回复
-
售SCI一区T0P文章，我:8.O.55.1.O54,科目全,可伽急
已经有6人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有5人回复
-
面上意见出来了
已经有16人回复
-
售SCI一区T0P文章，我:8.O55.1.O.54,科目全,可十急
已经有11人回复
frozenfox7
专家顾问 (正式写手)
-
专家经验: +56 - SFL-EPI: 1
- 应助: 31 (小学生)
- 金币: 4247.5
- 红花: 29
- 帖子: 478
- 在线: 119.1小时
- 虫号: 8497466
- 注册: 2018-04-10
- 性别: MM
- 专业: 基因组学
- 管辖: 专业外语
2楼2018-08-26 21:15:04
agar
金虫 (著名写手)
- SFL-EPI: 1
- 应助: 138 (高中生)
- 金币: 4078.8
- 散金: 4359
- 红花: 63
- 帖子: 2621
- 在线: 797小时
- 虫号: 111106
- 注册: 2005-11-20
- 性别: GG
- 专业: 生物信息学
【答案】应助回帖
★ ★
max_dolphin(空位代发): 金币+2, 感谢交流 2018-12-25 21:21:18
max_dolphin(空位代发): 金币+2, 感谢交流 2018-12-25 21:21:18
|
Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was known to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of conditions like acne and hirsutism. —————————————— Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9, transcription activator-like effector nucleases (TALEN), meganucleases, and zinc finger nucleases (ZFN).[1] These tools use different mechanisms to bind a predetermined sequence of DNA (“target”), which they cleave (or "cut"  , creating a double-stranded chromosomal break (DSB) that summons the cells DNA repair mechanisms (non-homologous end joining (NHEJ) and homologous recombination (HR)) and leads to site-specific modifications.[2] If these complexes do not bind at the target, often a result of homologous sequences and/or mismatch tolerance, they will cleave off-target DSB and cause non-specific genetic modifications.[3][4][5] Specifically, off-target effects consist of unintended point mutations,[6] deletions,[7][8] insertions[5] inversions,[5] and translocations.[9][8] |
3楼2018-08-28 23:26:50
