| 查看: 348 | 回复: 3 | |||
| 当前主题已经存档。 | |||
[交流]
求助：有关propofol的文章
|
|||
| 各位，急需有关propofol的文章。有关脂溶性方面的，及有关前药，哪位大侠帮帮我呀！ |
回复此楼» 猜你喜欢
售SCI一区T0P文章，我:8.O55.1.O.54,科目全,可十急
已经有7人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有5人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.54,科目齐全,可+急
已经有8人回复
-
咱们一起用铁证分析2026国家社科基金中标与否
已经有22人回复
-
是这周出结果还是下周出结果？
已经有4人回复
-
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有5人回复
-
欢迎发来filecode的Mz6后的代码验证其规律
已经有49人回复
-
哪位老哥知道今年的国自然具体哪一天放榜？
已经有5人回复
-
各位道友，我要去昆明玩几天，回来见。
已经有7人回复
-
filecode
已经有10人回复
大力水手2892
木虫 (著名写手)
- 应助: 0 (幼儿园)
- 金币: 6696.1
- 红花: 2
- 帖子: 1155
- 在线: 244小时
- 虫号: 728591
- 注册: 2009-03-22
- 专业: 药物学其他科学问题
2楼2009-03-29 02:00:12
3楼2009-04-03 21:28:45
mrzouhao
木虫之王 (文坛精英)
- PhEPI: 4
- 应助: 179 (高中生)
- 贵宾: 0.108
- 金币: 102348
- 散金: 11621
- 红花: 134
- 沙发: 23
- 帖子: 47323
- 在线: 4437.1小时
- 虫号: 201350
- 注册: 2006-02-28
- 专业: 药剂学
★
karl2100(金币+1,VIP+0):多谢提供！ 4-4 15:09
karl2100(金币+1,VIP+0):多谢提供！ 4-4 15:09
|
Anesth Analg 2002;95:1285-1292 © 2002 International Anesthesia Research Society -------------------------------------------------------------------------------- ANESTHETIC PHARMACOLOGY Propofol Phosphate, a Water-Soluble Propofol Prodrug: In Vivo Evaluation Mariusz G. Banaszczyk, PhD*, Alison T. Carlo*, Violeta Millan*, Adam Lindsey*, Ronald Moss, MD*, Dennis J. Carlo, PhD*, and Sheldon S. Hendler, MD PhD *The Immune Response Corporation, Carlsbad, California; and Vyrex Corporation, La Jolla, California Address correspondence and reprint requests to Mariusz G. Banaszczyk, PhD, Chemistry Department, The Immune Response Corporation, 5935 Darwin Court, Carlsbad, CA 92008. Address e-mail to mbanaszczyk@imnr.com. After a single IV injection of the water-soluble propofol prodrug propofol phosphate (PP) in mice, rats, rabbits, and pigs, propofol was produced rapidly (1–15 min), inducing dose-dependent sedative effects. In mice, the hypnotic dose (HD50), lethal dose (LD50), and safety index (defined as a ratio: LD50/HD50) were 165.4 mg/kg, 600.6 mg/kg, and 3.6, respectively. Propofol was produced with half-lives of 5.3 ± 0.6 min in rats, 2.1 ± 0.6 min in rabbits, and 4.4 ± 2.4 min in pigs. The maximal concentration was dose and species dependent. The elimination half-life was 24 ± 12 min in rats, 21 ± 16 min in rabbits, and 225 ± 56 min in pigs. Propofol generated from PP produced pharmacological effects similar to those described in the literature. We found a correlation between PP dose and duration of sedation with propofol concentrations larger than 1.0 µg/mL, which produced somnolence and sedation in rats and pigs. Adequate sedation and, at large enough doses, anesthetic-level sedation were produced after the administration of PP. Overall, PP, the water-soluble prodrug of propofol, seems to be a viable development candidate for sedative and anesthetic applications. IMPLICATIONS. Propofol phosphate, a water-soluble prodrug of the widely used IV anesthetic propofol, was developed and evaluated in mice, rats, rabbits, and pigs after IV injection. The results of the study clearly demonstrate the feasibility of the prodrug approach to achieve sedative and anesthetic levels of propofol in laboratory animals; this warrants further evaluation in humans. |
4楼2009-04-04 09:50:49
