| 查看: 294 | 回复: 3 | |||
| 当前主题已经存档。 | |||
[交流]
求助：有关propofol的文章
|
|||
| 各位，急需有关propofol的文章。有关脂溶性方面的，及有关前药，哪位大侠帮帮我呀！ |
回复此楼» 猜你喜欢
324分 085600材料与化工
已经有14人回复
-
总分343，求生物学调剂
已经有5人回复
-
262求调剂
已经有10人回复
-
302求调剂一志愿北航070300，本科郑大化学
已经有9人回复
-
英一数一408，总分284，二战真诚求调剂
已经有6人回复
-
285求调剂
已经有4人回复
-
289求调剂
已经有19人回复
-
301求调剂
已经有5人回复
-
292求调剂
已经有9人回复
-
309求调剂
已经有9人回复
大力水手2892
兑换贵宾
- 应助: 0 (幼儿园)
- 金币: 6321.1
- 红花: 2
- 帖子: 1155
- 在线: 236.3小时
- 虫号: 728591
- 注册: 2009-03-22
- 专业: 药物学其他科学问题
2楼2009-03-29 02:00:12
3楼2009-04-03 21:28:45
mrzouhao
主管区长
- PhEPI: 4
- 应助: 179 (高中生)
- 贵宾: 0.108
- 金币: 100882
- 散金: 11601
- 红花: 134
- 沙发: 22
- 帖子: 46786
- 在线: 4409.4小时
- 虫号: 201350
- 注册: 2006-02-28
- 专业: 药剂学
★
karl2100(金币+1,VIP+0):多谢提供！ 4-4 15:09
karl2100(金币+1,VIP+0):多谢提供！ 4-4 15:09
|
Anesth Analg 2002;95:1285-1292 © 2002 International Anesthesia Research Society -------------------------------------------------------------------------------- ANESTHETIC PHARMACOLOGY Propofol Phosphate, a Water-Soluble Propofol Prodrug: In Vivo Evaluation Mariusz G. Banaszczyk, PhD*, Alison T. Carlo*, Violeta Millan*, Adam Lindsey*, Ronald Moss, MD*, Dennis J. Carlo, PhD*, and Sheldon S. Hendler, MD PhD *The Immune Response Corporation, Carlsbad, California; and Vyrex Corporation, La Jolla, California Address correspondence and reprint requests to Mariusz G. Banaszczyk, PhD, Chemistry Department, The Immune Response Corporation, 5935 Darwin Court, Carlsbad, CA 92008. Address e-mail to mbanaszczyk@imnr.com. After a single IV injection of the water-soluble propofol prodrug propofol phosphate (PP) in mice, rats, rabbits, and pigs, propofol was produced rapidly (1–15 min), inducing dose-dependent sedative effects. In mice, the hypnotic dose (HD50), lethal dose (LD50), and safety index (defined as a ratio: LD50/HD50) were 165.4 mg/kg, 600.6 mg/kg, and 3.6, respectively. Propofol was produced with half-lives of 5.3 ± 0.6 min in rats, 2.1 ± 0.6 min in rabbits, and 4.4 ± 2.4 min in pigs. The maximal concentration was dose and species dependent. The elimination half-life was 24 ± 12 min in rats, 21 ± 16 min in rabbits, and 225 ± 56 min in pigs. Propofol generated from PP produced pharmacological effects similar to those described in the literature. We found a correlation between PP dose and duration of sedation with propofol concentrations larger than 1.0 µg/mL, which produced somnolence and sedation in rats and pigs. Adequate sedation and, at large enough doses, anesthetic-level sedation were produced after the administration of PP. Overall, PP, the water-soluble prodrug of propofol, seems to be a viable development candidate for sedative and anesthetic applications. IMPLICATIONS. Propofol phosphate, a water-soluble prodrug of the widely used IV anesthetic propofol, was developed and evaluated in mice, rats, rabbits, and pigs after IV injection. The results of the study clearly demonstrate the feasibility of the prodrug approach to achieve sedative and anesthetic levels of propofol in laboratory animals; this warrants further evaluation in humans. |
4楼2009-04-04 09:50:49
