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xrose木虫 (正式写手)
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Rheumatoid arthritis may be becoming milder
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SAN FRANCISCO - Drug companies make $2.5 billion a year selling Viagra, Cialis and Levitra to help men enjoy sex. Since more women suffer from sexual dysfunction than men, developing a drug that could double those sales would seem to be a no-brainer. Yet the pharmaceutical industry has failed women miserably — there isn’t a single sexual dysfunction drug on the market that can help them. Pfizer Inc. last year abandoned an eight-year Viagra study involving 3,000 women, conceding that its famous blue pill only works for men. “I hate to say it, but women are much more complex than men,” said Beverly Whipple, the sex researcher who co-wrote “The G-Spot.” Welsing, at Radboud University Nijmegen Medical Center, in the Netherlands, and colleagues investigated disease activity and disability of all newly diagnosed rheumatoid arthritis patients seen in their clinic from 1985 to 2005. A total of 525 subjects were included in the analysis. Patients seem to be seeking treatment earlier in the course of the disease, the authors report in the medical journal Arthritis & Rheumatism, with the duration of their symptoms having decreased from an average of 309 days two decades ago to 212 days in 2005. All components of a disease activity scale (except well-being) improved over the interval studied, the results indicate, both when the patients were first seen and 5 years after their diagnosis. Initial improvement in disease symptoms with treatment was also greater among more recently diagnosed patients, the researchers note, perhaps because the treatment strategy was more aggressive in more recent patients. “In our opinion there can be two reasons for the less severe disease activity at presentation in the more recent subpopulation of our study,” Welsing commented. “First, patients could come to a rheumatologist earlier after the onset of complaints. Further, it could be that patients with less severe complaints were in the past not referred to a rheumatologist and nowadays are referred to a rheumatologist.” “We cannot be certain that these two phenomena fully explain the decrease in disease activity at presentation,” Welsing said. His group is planning to study trends over time in the longer-term outcomes of rheumatoid arthritis. |
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