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Mass Spectrometry
for the Novice
作者John Greaves and John Roboz
页数306
出版社 CRC press
International Standard Book Number-13: 978-1-4200-9420-6 (eBook - PDF)
Contents
List of Figures......................................................................................................... xiii
List of Tables............................................................................................................xix
Acknowledgments....................................................................................................xxi
About the Authors................................................................................................. xxiii
Abbreviations..........................................................................................................xxv
To the Reader.........................................................................................................xxix
Chapter 1 An Overview.........................................................................................1
1.1 A Brief History...........................................................................1
1.2 Definitions Concerning Instruments, Mass, m/z, and Ions........2
1.3 Components of Instruments and Their Functions.................... 11
1.3.1 Sample Introduction.................................................... 11
1.3.2 Ion Sources.................................................................. 13
1.3.3 Mass Analyzers........................................................... 17
1.3.4 Ion Current Detectors.................................................. 21
1.3.5 Vacuum Systems.........................................................22
1.3.6 Data Systems...............................................................23
1.4 Definitions Concerning Instrument Performance....................23
1.5 Definitions Concerning Applications.......................................26
1.6 Information from Mass Spectra...............................................28
1.7 Diversity and Scope of Applications........................................ 31
Chapter 2 Instrumentation................................................................................... 35
2.1 Sample Introduction.................................................................37
2.1.1 Pure Samples or Simple Mixtures...............................37
2.1.1.1 Introduction of Gases and Volatile
Liquids Using Batch Inlets..........................37
2.1.1.2 Semipermeable Polymer Membrane Inlets.... 38
2.1.1.3 Direct (Static) Insertion Probes...................38
2.1.2 Chromatographic Separation of Complex Mixtures...39
2.1.2.1 Gas Chromatography–Mass
Spectrometry (GC-MS)...............................40
2.1.2.2 Liquid Chromatography–Mass
Spectrometry (LC-MS)................................ 43
2.1.2.3 Capillary Electrophoresis (CE).................... 45
2.2 Ion Sources and Methods of Ionization.................................... 45
2.2.1 Electron Ionization (EI)..............................................49
2.2.2 Soft Ionization............................................................. 52
2.2.2.1 Chemical Ionization (CI)............................. 53
2.2.2.2 Electrospray Ionization (ESI)......................56
? 2014 Taylor & Francis Group, LLC
viii Contents
2.2.2.3 Atmospheric Pressure Chemical
Ionization (APCI)........................................ 61?

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