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【求助】指点一下药物释放模拟
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有哪位高手可以发点指点药物释放模拟的推导过程的文章、 公式、方法等的东西给我吗？比如说应用Fick 1 ,Fick 2，Higuchi定律来对药物的释放进行模拟的方法等。 即通过数学的方法，对药物的释放进行模拟，从而达到预测药物释的目的，目前主要用到的方法有Fick1 Fick2 Higuchi定律等几种方法，望各大虾能发点经典的文章予以指导。 [ Last edited by wgcui on 2009-2-23 at 19:39 ] |
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2楼2009-02-24 10:29:50
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wgcui(金币+1,VIP+0):谢谢讨论 2-24 15:59
wgcui(金币+1,VIP+0):谢谢讨论 2-24 15:59
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Modeling the Loading and Unloading of Drugs into Nanotubes Small，2009，Volume 5 Issue 3, Pages 300 - 308 One of the most promising applications of nanotechnology is that of drug delivery, and in particular the targeted delivery of drugs using nanotubes. Functionalized nanotubes might be able to target specific cells, become ingested, and then release their contents in response to a chemical trigger. This will have significant implications for the future treatment of patients, particularly those suffering from cancer, for whom presently the nonspecific nature of chemotherapy often kills healthy normal cells. Research to date has largely been through experiments investigating toxicity, biocompatibility, solubility, functionalization, and cellular uptake. More recently, the loading and unloading of molecular cargo has gained momentum from both experimental and theoretical investigations. This Review focuses on the loading and unloading of molecular cargo and highlights recent theoretical investigations, which to date have received very little attention in the review literature. The development of nanotube drug-delivery capsules is of vital concern for the improvement of medical treatment, and mathematical modeling tends to facilitate such development and provides a quicker route to applications of the technology. This Review highlights the latest progress in terms of theoretical investigations and provides a focus for the development of the next generation of medical therapeutics. |
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4楼2009-02-24 16:05:38
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yusen_1982(金币+2,VIP+0):谢谢应助,欢迎常来 2-26 08:55
yusen_1982(金币+2,VIP+0):谢谢应助,欢迎常来 2-26 08:55
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UMN 制药系的大牛Ronald A. Siegel 就是专门做药物释放模型的优化的，你可以去看看他的文章 给你个链接吧 http://www.pharmacy.umn.edu/faculty/siegel_ronald/home.html |
6楼2009-02-26 08:45:31