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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
气沉丹田: 金币+20, ★★★★★最佳答案 2017-10-11 11:11:40
心静_依然: LS-EPI+1, 感谢应助 2017-10-11 12:19:41
Web of Science
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标题: The microRNA-635 suppresses tumorigenesis in non-small cell lung cancer
作者: Zhang, Y (Zhang, Yan); Sun, ZW (Sun, Zongwen); Zhang, YQ (Zhang, Yanqun); Fu, T (Fu, Tian); Liu, C (Liu, Cun); Liu, YR (Liu, Yongrui); Lin, Y (Lin, Yong)
来源出版物: BIOMEDICINE & PHARMACOTHERAPY 卷: 84 页: 1274-1281 DOI: 10.1016/j.biopha.2016.10.040 出版年: DEC 2016
Web of Science 核心合集中的 "被引频次": 2
被引频次合计: 2
使用次数 (最近 180 天): 1
使用次数 (2013 年至今): 3
引用的参考文献数: 35
摘要: The microRNAs represent a class of noncoding RNAs with short length and play diverse roles in many biological processes. Despite tremendous effects have been devoted, the role of miR-635 in non-small cell lung cancer (NSCLC) remains elusive. Here we report a potential tumor suppressive function of miR-635 in NSCLC. By microRNA screening based on invasion assays, we identified series of functional miRNAs. The miR-635 was then identified as a potent inhibitor of cell invasion and differentially expressed in normal and cancerous tissues. We further confirmed that Ying Yang 1 (YY1) may be the direct target of miR-635 as miR-635 transfection can significantly decrease endogenous YY1 expression which can mimic the effect of siRNA-mediated YY1 knockdown. Meanwhile, both miR-635 transfection and YY1 silencing can attenuate NSCLC cell invasion. In addition, miR-635 transfection can also significantly inhibit the growth of xenograft tumors. Taken together, our results have suggested a novel tumor suppressive role for miR-635 in NSCLC. (C) 2016 Elsevier Masson SAS. All rights reserved.
入藏号: WOS:000390438100149
PubMed ID: 27810784
语种: English
文献类型: Article
作者关键词: miR-635; Invasion; YY1; NSCLC
KeyWords Plus: NSCLC; METASTASIS; EXPRESSION; BIOMARKERS; INVASION; IDENTIFICATION; PROLIFERATION; PROGRESSION; STATISTICS; TUMORS
地址: [Zhang, Yan; Fu, Tian; Liu, Yongrui; Lin, Yong] Jining 1 Peoples Hosp, Dept Resp Med, 6 Hlth Rd, Jining 272011, Shandong, Peoples R China.
[Sun, Zongwen] Jining 1 Peoples Hosp, Dept Oncol, Jining 272011, Peoples R China.
[Zhang, Yanqun] Laiwu Peoples Hosp, Dept Hlth Care, Laiwu 271100, Peoples R China.
[Liu, Cun] Jining 1 Peoples Hosp, Dept Clin Lab, Jining 272011, Peoples R China.
通讯作者地址: Lin, Y (通讯作者),Jining 1 Peoples Hosp, Dept Resp Med, 6 Hlth Rd, Jining 272011, Shandong, Peoples R China.
电子邮件地址: linyong_jph@163.com
出版商: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
出版商地址: 23 RUE LINOIS, 75724 PARIS, FRANCE
Web of Science 类别: Medicine, Research & Experimental; Pharmacology & Pharmacy
研究方向: Research & Experimental Medicine; Pharmacology & Pharmacy
IDS 号: EF6JU
ISSN: 0753-3322
eISSN: 1950-6007
29 字符的来源出版物名称缩写: BIOMED PHARMACOTHER
ISO 来源出版物缩写: Biomed. Pharmacother.
来源出版物页码计数: 8
公开访问: No
输出日期: 2017-10-10 |
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