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求助分子生物学方面的英译汉【有效期2009年2月2０日】
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Genome-wide SNP genotype data provide a new approach for studying cis-regulatory sites. It has recently been shown7 that SNP density in exonic splicing enhancers is lower than expected, suggesting negative selection, but with the caveat that SNP density is sensitive to mutation rate biases (such as those due to base composition). Other groups used genotype data to demonstrate negative selection, as opposed to a lower mutation rate, on conserved noncoding regions, but they made no explicit connection to cis-regulatory sites These studies examined only the average intensity of selection on an entire class of elements and not the distribution of selective effects within the class. [ Last edited by 南方嘉木 on 2009-2-18 at 11:37 ] |
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