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Abstract: Atazanavir sulfate is a novel azapeptide protease inhibitor (PIS) with high selection and efficiency, alone or in combination with other antiretroviral treatment of experienced patients with multiple resistance mutations to PIS. In this paper, physicochemical properties, mechanism of action, synthetic methods of atazanavir sulfate and synthetic methods of its intermediates are introduced.

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2Â¥2017-06-19 21:13:10
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genhunter

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Abstract:

In this paper, we provide an overview on atazanavir sulfate, a novel azapeptide protease inhibitor, including the physicochemical properties, crystalline type, synthesis methods for the main intermediates (2R, 3S) -Boc [name is English epoxide (2R, 3S) -3- (tert-butoxycarbonyl) amino- 1, 2-epoxy- 4- phenylbutane)] and the finished product, current market for the active pharmaceutical ingredient and the main intermediates, R&D efforts at home and abroad,  and clinical applications for AIDS patients. At the end of the article we also provide a  critical analysis of atazanavir sulfate.
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baiyuefei: ½ð±Ò+130, ·­ÒëEPI+1, ¡ï¡ï¡ïºÜÓаïÖú 2017-06-20 10:33:28
ÒýÓûØÌû:
3Â¥: Originally posted by genhunter at 2017-06-20 08:42:44
Abstract:

In this paper, we provide an overview on atazanavir sulfate, a novel azapeptide protease inhibitor, including the physicochemical properties, crystalline type, synthesis methods for the ...

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Abstract:

In this paper, we provide an overview on atazanavir sulfate, a novel azapeptide protease inhibitor, including the physicochemical properties, crystalline type, synthesis methods for the main intermediates (2R, 3S) -Boc [epoxide (2R, 3S) -3- (tert-butoxycarbonyl) amino- 1, 2-epoxy- 4- phenylbutane)] and the finished product, current market for the active pharmaceutical ingredient and the main intermediates, R&D efforts at home and abroad,  and clinical applications for AIDS patients. At the end of the article we also provide a  critical analysis of atazanavir sulfate.
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4Â¥2017-06-20 09:15:10
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5Â¥2017-06-20 09:24:27
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baiyuefei: ½ð±Ò+70, ¡ï¡ï¡ïºÜÓаïÖú 2017-06-20 10:33:41
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Abstract: Atazanavir sulfate is a novel azapeptide protease inhibitor (PIS) with high selection and efficiency, alone or in combination with other antiretroviral treatment of experienced patients with multiple resistance mutations to PIS. In this paper, physicochemical properties, mechanism of action, synthetic methods of atazanavir sulfate and synthetic methods of its intermediates are introduced.


Abstract: Atazanavir sulfate is a novel azapeptide protease inhibitor (PIS) with high selection and efficiency,l it can be applied, alone or in combination with other antiretroviral drugs, to Aids patients, especially those avaliable-antiretrovira-drug-not-effected. This paper maily viewed the physicochemical properties, mechanism of action, crystal, and the synthetic methods of main intermediate ((2R,3S)-3-(tert-butoxycarbonyl)amino- 1, 2-epoxy- 4- phenylbutane)  of atazanavir sulfate. It also presented the Swo analysis of atazanavir sulfate.
6Â¥2017-06-20 09:42:34
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

genhunter

ÖÁ×ðľ³æ (ÖøÃûдÊÖ)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

ÒýÓûØÌû:
4Â¥: Originally posted by genhunter at 2017-06-20 09:15:10
¸ÄÒ»ÏÂ

Abstract:

In this paper, we provide an overview on atazanavir sulfate, a novel azapeptide protease inhibitor, including the physicochemical properties, crystalline type, synthesis meth ...

ÔÙ¸ÄÒ»ÏÂ:

In this paper, we provide an overview on atazanavir sulfate, a novel azapeptide protease inhibitor with high selectivity and efficacy, used in clinic alone or in combination with other anti-retroviral agents, for the treatment of AIDS patients with multiple drug resistance mutations who are non-response to current  protease inhibitors. We provide detailed information on the physicochemical properties, crystalline type, synthesis methods for the main intermediates (2R, 3S) -Boc [epoxide (2R, 3S) -3- (tert-butoxycarbonyl) amino- 1, 2-epoxy- 4- phenylbutane)] and the finished product, current market for the active pharmaceutical ingredient and the main intermediates, R&D efforts at home and abroad,  and clinical applications for AIDS patients. At the end of the article we also provide a  critical analysis of atazanavir sulfate.
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7Â¥2017-06-20 10:26:06
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
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